WO2026051873 - ASIATIC-ACID-DERIVED CERAMIDE, AND SYNTHESIS METHOD THEREFOR AND USE THEREOF
National phase entry is expected:
Publication Number
WO/2026/051873
Publication Date
12.03.2026
International Application No.
PCT/CN2025/118137
International Filing Date
01.09.2025
Title **
[English]
ASIATIC-ACID-DERIVED CERAMIDE, AND SYNTHESIS METHOD THEREFOR AND USE THEREOF
[French]
CÉRAMIDE DÉRIVÉ D'ACIDE ASIATIQUE, SON PROCÉDÉ DE SYNTHÈSE ET SON UTILISATION
[Chinese]
积雪草酸衍生的神经酰胺及其合成方法和应用
Applicants **
SHENZHEN DIKEMAN BIOTECHNOLOGY CO., LTD.
Inventors
YE, Liu
YANG, Chaowen
LI, Can
Priority Data
202411253426.8
09.09.2024
CN
Application details
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International Searching Authority |
CNIPA
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 1576 | |
| EPO | Filing, Examination, Granting | 11576 | |
| Japan | Filing, Examination, Granting | 2001 | |
| South Korea | Filing, Examination, Granting | 1805 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
21,698
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Abstract[English]
is hydroxyl or a hydrogen atom. Further disclosed in the present invention are a method for synthesizing the asiatic-acid-derived ceramide and the use thereof. By means of the present invention, the solubility of ceramide is improved by means of introducing an asiatic acid or madecassic acid fragment with good fat solubility, thereby facilitating the use of ceramide in formulations. The compound of the present invention exhibits a significant inhibitory effect on inflammatory cytokine interleukin-6 (IL-6), and can also suppress the overexpression of TRPV1 receptors in sensitive skin and significantly reduce the expression of hyaluronidase, thereby achieving a good soothing effect.[French]
est un hydroxyle ou un atome d'hydrogène. La présente invention concerne en outre un procédé de synthèse du céramide dérivé d'acide asiatique et son utilisation. La présente invention permet d'obtenir une solubilité améliorée du céramide par introduction d'un acide asiatique ou d'un fragment d'acide madécassique ayant une bonne solubilité dans la graisse, ce qui facilite l'utilisation de céramide dans des formulations. Le composé selon la présente invention présente un effet inhibiteur significatif sur l'interleukine-6 de cytokine inflammatoire (IL-6), et peut également supprimer la surexpression des récepteurs TRPV1 dans la peau sensible et réduire significativement l'expression de hyaluronidase, ce qui permet d'obtenir un bon effet apaisant.[Chinese]
为羟基或氢原子。本发明还公开了积雪草酸衍生的神经酰胺的合成方法和应用，本发明通过引入脂溶性较好的积雪草酸或羟基积雪草酸片段，改善了神经酰胺的溶解性，使其在配方中的应用更为方便；本发明的化合物对白介素6(IL-6)炎症因子具有明显的抑制作用，还能够抑制敏感皮肤TRPV1感受器的过量表达，可明显降低透明质酸酶的表达，从而具有很好的舒缓功效。