WO2026021423 - INTERMEDIATE FOR SYNTHESIZING NAV1.8 INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF
National phase entry is expected:
Publication Number
WO/2026/021423
Publication Date
29.01.2026
International Application No.
PCT/CN2025/109813
International Filing Date
22.07.2025
Title **
[English]
INTERMEDIATE FOR SYNTHESIZING NAV1.8 INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF
[French]
INTERMÉDIAIRE POUR SYNTHÉTISER UN INHIBITEUR DE NAV1.8, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
[Chinese]
一种合成Nav1.8抑制剂的中间体，其制备方法和用途
Applicants **
CHENGDU KANGHONG PHARMACEUTICAL CO LTD
Inventors
KE, Xiao
LI, Mengqiang
FENG, Jie
LIU, Ting
LAN, Yangshan
YANG, Honglin
LI, Chao
Priority Data
202410991337.7
23.07.2024
CN
Application details
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International Searching Authority |
CNIPA
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2142 | |
| EPO | Filing, Examination, Granting | 18369 | |
| Japan | Filing, Examination, Granting | 2553 | |
| South Korea | Filing, Examination, Granting | 3001 | |
| USA | Filing, Examination, Granting | 6340 |
Total:
32,405
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Abstract[English]
The present invention relates to the pharmaceutical field, and provides an intermediate for synthesizing a Nav1.8 inhibitor, a preparation method therefor, and a use thereof. The present invention provides a compound represented by formula I. The compound can be used for synthesizing a Nav1.8 inhibitor represented by formula (II), and is a novel intermediate for synthesizing the Nav1.8 inhibitor. The compound represented by formula I of the present invention can be readily prepared by means of an amide condensation reaction. A method for preparing the Nav1.8 inhibitor by using the compound represented by formula I as a raw material is characterized by short steps, mild reaction conditions, simple post-treatment and purification, high conversion rate, and suitability for industrial production.[French]
La présente invention relève du domaine pharmaceutique, et concerne un intermédiaire pour synthétiser un inhibiteur de Nav1.8, son procédé de préparation et son utilisation. La présente invention concerne un composé représenté par la formule I. Le composé peut être utilisé pour synthétiser un inhibiteur de Nav1.8 représenté par la formule (II), et est un nouvel intermédiaire pour synthétiser l'inhibiteur de Nav1.8. Le composé représenté par la formule I selon la présente invention peut être facilement préparé au moyen d'une réaction de condensation d'amide. Un procédé de préparation de l'inhibiteur de Nav1.8 à l'aide du composé représenté par la formule I en tant que matière première est caractérisé par des étapes courtes, des conditions de réaction modérées, un post-traitement et une purification simples, un taux de conversion élevé et une aptitude à la production industrielle.[Chinese]
本发明提供一种用于合成Nav1.8抑制剂的中间体，以及该中间体的制备方法和用途，属于制药领域。本发明提供了式I所示的化合物该化合物能够用于合成式(Ⅱ)所示Nav1.8抑制剂是合成Nav1.8抑制剂的新中间体，本发明式I所示化合物可容易地通过酰胺缩合反应制得，且以式I所示化合物为原料制备Nav1.8抑制剂的方法步骤简短，反应条件温和，后处理和纯化简单，转化率高，适合工业化生产。