WO2026012411 - EXATECAN DERIVATIVE AND USE THEREOF

National phase entry is expected:
Publication Number WO/2026/012411
Publication Date 15.01.2026
International Application No. PCT/CN2025/107799
International Filing Date 10.07.2025
Title **
[English] EXATECAN DERIVATIVE AND USE THEREOF
[French] DÉRIVÉ D'EXATÉCAN ET SON UTILISATION
[Chinese] 依喜替康衍生物及其用途
Applicants **
SHANGHAI HUAOTA BIOPHARMACEUTICAL CO., LTD.
HUABO BIOPHARM (SHANGHAI) CO., LTD.
Inventors
ZHENG, Changping
XU, Jingen
PENG, Guoyuan
ZHAN, Yifan
ZHU, Xiangyang
Priority Data
202410935181.0   11.07.2024   CN
Application details
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Translation

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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting1697
EPO Filing, Examination, Granting11880
Japan Filing, Examination, Granting2030
South Korea Filing, Examination, Granting1867
USA Filing, Examination, Granting4740
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Total: 22,214
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Abstract[English] The present application relates to an exatecan derivative having a structure as represented by formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. The present application further relates to an ADC of the exatecan derivative, a pharmaceutical composition, a preparation method therefor and the use thereof.[French] La présente demande concerne un dérivé d'exatécan ayant une structure telle que représentée par la formule (I), ou un stéréoisomère de celui-ci, ou un sel pharmaceutiquement acceptable de celui-ci. La présente demande concerne en outre un ADC du dérivé d'exatécan, une composition pharmaceutique, un procédé de préparation correspondant et une utilisation associée.[Chinese] 本申请涉及一种依喜替康衍生物,具有式(I)所示的结构,或其立体异构体、或其药学上可接受的盐。本申请还涉及所述依喜替康衍生物的ADC、药物组合物、制备方法以及用途。