WO2025252179 - EXTRACELLULAR VESICLE, PREPARATION METHOD THEREFOR, AND USE THEREOF
National phase entry is expected:
Publication Number
WO/2025/252179
Publication Date
11.12.2025
International Application No.
PCT/CN2025/099437
International Filing Date
05.06.2025
Title **
[English]
EXTRACELLULAR VESICLE, PREPARATION METHOD THEREFOR, AND USE THEREOF
[French]
VÉSICULE EXTRACELLULAIRE, PROCÉDÉ DE PRÉPARATION S'Y RAPPORTANT ET UTILISATION ASSOCIÉE
[Chinese]
一种细胞外囊泡及其制备方法与应用
Applicants **
SHENZHEN GENOCURY BIOTECH CO., LTD
Inventors
HUANG, Ke
ZHANG, Tian
Priority Data
202410724879.8
05.06.2024
CN
Application details
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International Searching Authority |
CNIPA
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2736 | |
| EPO | Filing, Examination, Granting | 26710 | |
| Japan | Filing, Examination, Granting | 3016 | |
| South Korea | Filing, Examination, Granting | 3997 | |
| USA | Filing, Examination, Granting | 9340 |
Total:
45,799
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Abstract[English]
An extracellular vesicle. The surface of the extracellular vesicle comprises at least part of a viral envelope glycoprotein or a variant thereof; the at least part of the viral envelope glycoprotein or the variant thereof does not bind to a receptor or the binding to a receptor is inhibited; and the extracellular vesicle is difficult to infect a cell by binding to a glycoprotein receptor. When the extracellular vesicle is used for delivering a target protein, the targeting performance of the extracellular vesicle is significantly improved. When an extracellular vesicle membrane expresses a hydrophobic protein, the expression and purification of the hydrophobic protein are facilitated.[French]
L'invention concerne une vésicule extracellulaire. La surface de la vésicule extracellulaire comprend au moins une partie d'une glycoprotéine d'enveloppe virale ou d'un variant de celle-ci ; l'au moins une partie de la glycoprotéine d'enveloppe virale ou de son variant ne se lie pas à un récepteur ou la liaison à un récepteur est inhibée ; et il est difficile pour la vésicule extracellulaire d'infecter une cellule par liaison à un récepteur de glycoprotéine. Lorsque la vésicule extracellulaire est utilisée pour administrer une protéine cible, les performances de ciblage de la vésicule extracellulaire sont significativement améliorées. Lorsqu'une membrane de vésicule extracellulaire exprime une protéine hydrophobe, l'expression et la purification de la protéine hydrophobe sont facilitées.[Chinese]
一种细胞外囊泡，其表面包含包膜病毒糖蛋白或其变体的至少一部分，包膜病毒糖蛋白或其变体的至少一部分不结合受体或与受体的结合被抑制，细胞外囊泡难以通过结合糖蛋白受体而感染细胞。当被用于运输目的蛋白时，细胞外囊泡的靶向性显著提高。细胞外囊泡膜表达疏水性蛋白时，更有利于疏水性蛋白的表达和纯化。