WO2026031745 - METHOD FOR PREPARING NITROGEN-BRANCHED TWO-ARM POLYETHYLENE GLYCOL DERIVATIVE
National phase entry is expected:
Publication Number
WO/2026/031745
Publication Date
12.02.2026
International Application No.
PCT/CN2025/098543
International Filing Date
30.05.2025
Title **
[English]
METHOD FOR PREPARING NITROGEN-BRANCHED TWO-ARM POLYETHYLENE GLYCOL DERIVATIVE
[French]
PROCÉDÉ DE PRÉPARATION D'UN DÉRIVÉ DE POLYÉTHYLÈNE GLYCOL À DEUX BRAS À RAMIFICATION AZOTE
[Chinese]
一种氮支化两臂聚乙二醇衍生物的制备方法
Applicants **
XIAMEN SINOPEG BIOTECH CO., LTD
Inventors
ZHU, Qi
LIN, Sheng
CHEN, Dandan
WANG, Ailan
LIN, Minggui
WEI, Guohua
WENG, Wengui
LIU, Chao
Priority Data
202411094026.7
09.08.2024
CN
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International Searching Authority |
CNIPA
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The Standard Agent's Assignment
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Legal Entity
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| Entry into National Phase under |
Chapter I
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Send the Letters Patent by Courier
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2186 | |
| EPO | Filing, Examination, Granting | 18880 | |
| Japan | Filing, Examination, Granting | 2584 | |
| South Korea | Filing, Examination, Granting | 3067 | |
| USA | Filing, Examination, Granting | 6540 |
Total:
33,257
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Abstract[English]
Disclosed in the present invention is a method for preparing a nitrogen-branched two-arm polyethylene glycol derivative. The nitrogen-branched two-arm polyethylene glycol derivative is as represented by general formula (1), and the method comprises a reaction between P-amide and BSM. The P-amide is a linear polyethylene glycol derivative containing an amide bond, and the BSM is a bifunctionalized small molecule compound. The definition of each symbol is as described herein. The present invention overcomes, by means of the rational design of reaction routes and reaction conditions, problems such as difficulty in separation and purification during the synthesis of analogous target products. Moreover, the present invention has the advantages of simple operation, high product purity, and high functionalization modification rate.[French]
La présente invention divulgue un procédé de préparation d'un dérivé de polyéthylène glycol à deux bras à ramification azote. Le dérivé de polyéthylène glycol à deux bras à ramification azote est tel que représenté par la formule générale (1), et le procédé comprend une réaction entre P-amide et BSM. Le P-amide est un dérivé de polyéthylène glycol linéaire contenant une liaison amide, et le BSM est un composé à petites molécules bifonctionnalisé. La définition de chaque symbole est telle que décrite dans la description. La présente invention surmonte, au moyen de la conception rationnelle des voies de réaction et des conditions de réaction, des problèmes tels que la difficulté de séparation et de purification pendant la synthèse de produits cibles analogues. De plus, la présente invention présente les avantages d'un fonctionnement simple, d'une pureté de produit élevée, et d'un taux de modification de fonctionnalisation élevé.[Chinese]
本发明公开了一种氮支化两臂聚乙二醇衍生物的制备方法。所述氮支化两臂聚乙二醇衍生物如通式(1)所示，且所述方法包括P-amide和BSM之间的反应。其中，P-amide为含有酰胺键的线性聚乙二醇衍生物，BSM为双官能化小分子化合物。各符号的定义如文中所述。本发明通过对反应路线和反应条件的合理设计克服了同类目标产品合成中分离纯化难等问题，同时具备操作简单、产品纯度高和官能化修饰率高的优点。