WO2025247303 - HUMAN SIGNAL REGULATORY PROTEIN ALPHA MUTANT HAVING PH-DEPENDENT BINDING ACTIVITY AND USE THEREOF
National phase entry is expected:
Publication Number
WO/2025/247303
Publication Date
04.12.2025
International Application No.
PCT/CN2025/097912
International Filing Date
29.05.2025
Title **
[English]
HUMAN SIGNAL REGULATORY PROTEIN ALPHA MUTANT HAVING PH-DEPENDENT BINDING ACTIVITY AND USE THEREOF
[French]
MUTANT DE PROTÉINE RÉGULATRICE DE SIGNAL ALPHA HUMAIN AYANT UNE ACTIVITÉ DE LIAISON DÉPENDANTE DU PH ET SON UTILISATION
[Chinese]
具有pH依赖结合活性的人信号调节蛋白α突变体及其应用
Applicants **
SHANGHAI AILUX BIOTECHNOLOGY CO., LTD.
Inventors
SU, Hang
LI, Lulu
WANG, Liujing
XU, Zhiqiang
AN, Zhaojun
YU, Quan
ZHU, Yupeng
ZHANG, Xiaojin
LI, Yi
Priority Data
202410695510.9
30.05.2024
CN
202411055675.6
01.08.2024
CN
202510112310.0
23.01.2025
CN
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
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| Number of Pages with Drawings | * |
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| Number of Office Actions | * |
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International Searching Authority |
CNIPA
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2173 | |
| EPO | Filing, Examination, Granting | 12964 | |
| Japan | Filing, Examination, Granting | 2153 | |
| South Korea | Filing, Examination, Granting | 2203 | |
| USA | Filing, Examination, Granting | 5940 |
Total:
25,433
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Abstract[English]
Provided is a mutant of an immunoglobulin-like variable domain of a signal regulatory protein alpha (SIRPαV), which mutant, relative to wild-type SIRPαV, contains histidine (H) at at least one position corresponding to amino acid positions 29, 31, 36, 37, 51, 52, 53, 68, 69, 95 and 99 as set forth in SEQ ID NO: 1.[French]
L'invention concerne un mutant d'un domaine variable de type immunoglobuline d'une protéine régulatrice de signal alpha (SIRPαV), lequel mutant, par rapport au SIRPαV de type sauvage, contient de l'histidine (H) à au moins une position correspondant aux positions d'acides aminés 29, 31, 36, 37, 51, 52, 53, 68, 69, 95 et 99 comme décrit dans SEQ ID NO : 1.[Chinese]
提供了信号调节蛋白α的免疫球蛋白样可变结构域(SIRPαV)的突变体，其相对于野生型SIRPαV，在对应于SEQ ID NO:1所示氨基酸位置29、31、36、37、51、52、53、68、69、95和99的至少一个位置处包含组氨酸(H)。