WO2025209590 - VIRAL VECTOR PACKAGING SYSTEM AND USE THEREOF
National phase entry is expected:
Publication Number
WO/2025/209590
Publication Date
09.10.2025
International Application No.
PCT/CN2025/087359
International Filing Date
03.04.2025
Title **
[English]
VIRAL VECTOR PACKAGING SYSTEM AND USE THEREOF
[French]
SYSTÈME D'ENCAPSIDATION DE VECTEUR VIRAL ET SON UTILISATION
[Chinese]
一种病毒载体包装系统及其应用
Applicants **
SHENZHEN GENOCURY BIOTECH CO., LTD
Inventors
HUANG, Ke
LI, Yuhang
Priority Data
202410403455.1
03.04.2024
CN
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
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| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
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International Searching Authority |
CNIPA
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 8105 | |
| EPO | Filing, Examination, Granting | 256525 | |
| Japan | Filing, Examination, Granting | 5486 | |
| South Korea | Filing, Examination, Granting | 15528 | |
| USA | Filing, Examination, Granting | 49240 |
Total:
334,884
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Abstract[English]
Provided are a packaging system for packaging a lentiviral vector or a retroviral vector, and a use of the packaging system. Specifically, the provided packaging system comprises a polynucleotide encoding a CAR binding molecule, wherein the CAR binding molecule can bind to a CAR. Pseudotransduction is reduced when a host cell is transduced by the lentiviral vector or the retroviral vector packaged by the provided packaging system, and the ability to transduce a target cell expressing an antigen decreases, thereby significantly improving the targeting performance of the lentiviral vector or the retroviral vector in the transduction of immune cells such as T cells.[French]
L'invention concerne un système d'encapsidation pour encapsider un vecteur lentiviral ou un vecteur rétroviral, et une utilisation du système d'encapsidation. Plus particulièrement, le système d'encapsidation selon l'invention comprend un polynucléotide codant pour une molécule de liaison à CAR, la molécule de liaison à CAR pouvant se lier à un CAR. La pseudotransduction est réduite lorsqu'une cellule hôte est transduite par le vecteur lentiviral ou le vecteur rétroviral encapsidé par le système d'encapsidation fourni, et l'aptitude à transduire une cellule cible exprimant un antigène diminue, ce qui permet d'améliorer significativement les performances de ciblage du vecteur lentiviral ou du vecteur rétroviral dans la transduction de cellules immunitaires telles que des lymphocytes T.[Chinese]
提供了一种用于包装慢病毒载体或逆转录病毒载体的包装系统及其应用。具体地，提供的包装系统包含编码CAR结合分子的多核苷酸，所述CAR结合分子可结合CAR；提供的包装系统包装的慢病毒载体或逆转录病毒载体转导宿主细胞时的假转导减少，并且转导表达抗原的靶细胞的能力减弱，显著提高了所述慢病毒载体或逆转录病毒载体转导T细胞等免疫细胞的靶向性。