WO2025131039 - POLYBORON COMPLEX, AND PREPARATION AND USE THEREOF
National phase entry is expected:
Publication Number
WO/2025/131039
Publication Date
26.06.2025
International Application No.
PCT/CN2024/140891
International Filing Date
20.12.2024
Title **
[English]
POLYBORON COMPLEX, AND PREPARATION AND USE THEREOF
[French]
COMPLEXE DE POLYBORE, SA PRÉPARATION ET SON UTILISATION
[Chinese]
一种多硼络合物及其制备和应用
Applicants **
NEUBORON MEDTECH RESEARCH INSTITUTE LTD.
Inventors
YUAN, Zhenwei
LIU, Ji
LIN, Jingjing
WANG, Yuxin
Priority Data
202311796655.X
23.12.2023
CN
202411848572.5
13.12.2024
CN
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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| Number of Office Actions | * |
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International Searching Authority |
CNIPA
* |
| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
* |
| Type of Assignment |
The Standard Agent's Assignment
* |
| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
* |
| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2468 | |
| EPO | Filing, Examination, Granting | 18214 | |
| Japan | Filing, Examination, Granting | 2464 | |
| South Korea | Filing, Examination, Granting | 2835 | |
| USA | Filing, Examination, Granting | 5740 |
Total:
31,721
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
Provided in the present invention are a polyboron complex or a stereoisomer, a deuterated compound or a pharmaceutically acceptable salt thereof, and the preparation and the use thereof. The polyboron complex of the present invention has a relatively low biotoxicity, and has a relatively high T/B ratio and boron enrichment level in tumor cells. The structure of the polyboron complex is as shown in the following formula (I).[French]
La présente invention concerne un complexe de polybore ou un stéréoisomère, un composé deutéré ou un sel pharmaceutiquement acceptable de celui-ci, et sa préparation et son utilisation. Le complexe de polybore de la présente invention a une biotoxicité relativement faible, et possède un rapport T/B et un niveau d'enrichissement en bore relativement élevés dans des cellules tumorales. La structure du complexe de polybore est telle que représentée dans la formule (I) suivante.[Chinese]
本发明提供了一种多硼络合物或其立体异构体、氘代物或药学上可接受的盐及其制备和应用。本发明所述多硼络合物生物毒性较低，在肿瘤细胞中具有较高的T/B比和硼富集量。所述多硼络合物结构如下式(I)所示。