WO2025108284 - COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF SODIUM VOLTAGE-GATED CHANNEL ALPHA SUBUNIT 9 (SCN9A)
National phase entry:
Publication Number
WO/2025/108284
Publication Date
30.05.2025
International Application No.
PCT/CN2024/133074
International Filing Date
20.11.2024
Title **
[English]
COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF SODIUM VOLTAGE-GATED CHANNEL ALPHA SUBUNIT 9 (SCN9A)
[French]
COMPOSITIONS ET PROCÉDÉS D'INHIBITION DE L'EXPRESSION DE LA SOUS-UNITÉ 9 DU CANAL SODIQUE VOLTAGE-DÉPENDANT (SCN9A)
Applicants **
SHANGHAI ARGO BIOPHARMACEUTICAL CO., LTD.
Inventors
SHU, Dongxu
SHAO, Pengcheng Patrick
XIA, Shiwei
Priority Data
PCT/CN2023/132649
20.11.2023
CN
PCT/CN2024/122315
29.09.2024
CN
Application details
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International Searching Authority |
CNIPA
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 4712 | |
| EPO | Filing, Examination, Granting | 69294 | |
| Japan | Filing, Examination, Granting | 4097 | |
| South Korea | Filing, Examination, Granting | 6336 | |
| USA | Filing, Examination, Granting | 22040 |
Total:
106,479
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
Compositions and methods useful to reduce expression of sodium voltage-gated channel alpha subunit 9 (SCN9A) gene and for treatment of SCN9A-associated diseases and conditions are provided. Provided are SCN9A dsRNA agents, SCN9A antisense polynucleotide agents, compositions comprising SCN9A dsRNA agents, and compositions comprising SCN9A antisense polynucleotide agents that can be used to reduce SCN9A expression in cells and subjects.[French]
L'invention concerne des compositions et des procédés utiles pour réduire l'expression du gène de la sous-unité 9 du canal sodique voltage-dépendant (SCN9A) et pour le traitement de maladies et d'états associés à SCN9A. L'invention concerne des agents ARNdb SCN9A, des agents polynucléotidiques antisens SCN9A, des compositions comprenant des agents ARNdb SCN9A, et des compositions comprenant des agents polynucléotidiques antisens SCN9A qui peuvent être utilisés pour réduire l'expression de SCN9A dans des cellules et chez des sujets.