WO2025039676 - PAN-KRAS PROTEIN TARGETED DEGRADER COMPOUND AND USE THEREOF
National phase entry is expected:
Publication Number
WO/2025/039676
Publication Date
27.02.2025
International Application No.
PCT/CN2024/097694
International Filing Date
06.06.2024
Title **
[English]
PAN-KRAS PROTEIN TARGETED DEGRADER COMPOUND AND USE THEREOF
[French]
COMPOSÉ DE DÉGRADATION CIBLÉ DE PROTÉINE PAN-KRAS ET SON UTILISATION
[Chinese]
一种靶向泛KRAS蛋白降解剂的化合物及其应用
Applicants **
BETTA PHARMACEUTICALS CO., LTD
355 Xingzhong Rd., Linping
Hangzhou, Zhejiang 311100, CN
Inventors
XU, Renqi
355 Xingzhong Rd., Linping
Hangzhou, Zhejiang 311100, CN
YANG, Xiaofeng
355 Xingzhong Rd., Linping
Hangzhou, Zhejiang 311100, CN
ZHANG, Hongbo
355 Xingzhong Rd., Linping
Hangzhou, Zhejiang 311100, CN
LU, Lu
355 Xingzhong Rd., Linping
Hangzhou, Zhejiang 311100, CN
ZHENG, Hang
355 Xingzhong Rd., Linping
Hangzhou, Zhejiang 311100, CN
WANG, Ze
355 Xingzhong Rd., Linping
Hangzhou, Zhejiang 311100, CN
WANG, Wei
355 Xingzhong Rd., Linping
Hangzhou, Zhejiang 311100, CN
LI, Shusen
355 Xingzhong Rd., Linping
Hangzhou, Zhejiang 311100, CN
HE, Jiangqi
355 Xingzhong Rd., Linping
Hangzhou, Zhejiang 311100, CN
SHI, Zhaotao
355 Xingzhong Rd., Linping
Hangzhou, Zhejiang 311100, CN
WANG, Dong
355 Xingzhong Rd., Linping
Hangzhou, Zhejiang 311100, CN
LIN, Yuanwang
355 Xingzhong Rd., Linping
Hangzhou, Zhejiang 311100, CN
LI, Tengfei
355 Xingzhong Rd., Linping
Hangzhou, Zhejiang 311100, CN
FANG, Longcheng
355 Xingzhong Rd., Linping
Hangzhou, Zhejiang 311100, CN
TAN, Yaoming
355 Xingzhong Rd., Linping
Hangzhou, Zhejiang 311100, CN
XU, Yanjie
355 Xingzhong Rd., Linping
Hangzhou, Zhejiang 311100, CN
XIA, Hongfeng
355 Xingzhong Rd., Linping
Hangzhou, Zhejiang 311100, CN
LU, Yuan
355 Xingzhong Rd., Linping
Hangzhou, Zhejiang 311100, CN
WU, Hao
355 Xingzhong Rd., Linping
Hangzhou, Zhejiang 311100, CN
ZHOU, Quan
355 Xingzhong Rd., Linping
Hangzhou, Zhejiang 311100, CN
LAN, Hong
355 Xingzhong Rd., Linping
Hangzhou, Zhejiang 311100, CN
WANG, Jiabing
Building 29, Zone B, 1 North Disheng Rd.
Daxing District, Beijing 100176, CN
DING, Lieming
355 Xingzhong Rd., Linping
Hangzhou, Zhejiang 311100, CN
Priority Data
202311043105.0
18.08.2023
CN
202311266772.5
28.09.2023
CN
202410100382.9
24.01.2024
CN
202410623723.0
17.05.2024
CN
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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International Searching Authority |
CNIPA
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| Applicant's Legal Status |
Legal Entity
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| * | |
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| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Translation |
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Recalculate
* The data is based on automatic recognition. Please verify and amend if necessary.
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 4972 | |
| EPO | Filing, Examination | 23893 | |
| Japan | Filing | 600 | |
| South Korea | Filing | 675 | |
| USA | Filing, Examination | 10735 |
Total: 40875 USD
Abstract[English]
The present invention relates to a pan-KRAS protein targeted modulator compound and the use thereof. Specifically, the present invention relates to a pan-KRAS protein targeted modulator compound as shown in general formula (A), a preparation method therefor, and the pharmaceutical use thereof.[French]
La présente invention concerne un composé modulateur ciblé de protéine pan-KRAS et son utilisation. Plus particulièrement, la présente invention concerne un composé modulateur ciblé de protéine pan-KRAS tel que représenté dans la formule générale (A), son procédé de préparation et son utilisation pharmaceutique.[Chinese]
涉及一种靶向泛KRAS蛋白调节剂的化合物及其应用。具体而言，涉及一种含有通式(A)所示的靶向泛KRAS蛋白调节剂化合物、其制备方法，及其在医药上的应用。