WO2024244953 - A REACTION PROCESS AND BIOCATALYST FOR PREPARING ENANTIOPURE (S) -4-PHENYL-2-OXAZOLIDINONE
National phase entry is expected:
Publication Number
WO/2024/244953
Publication Date
05.12.2024
International Application No.
PCT/CN2024/092820
International Filing Date
13.05.2024
Title **
[English]
A REACTION PROCESS AND BIOCATALYST FOR PREPARING ENANTIOPURE (S) -4-PHENYL-2-OXAZOLIDINONE
[French]
PROCÉDÉ DE RÉACTION ET BIOCATALYSEUR POUR LA PRÉPARATION DE (S) -4-PHÉNYL-2-OXAZOLIDINONE ÉNANTIOPURE
Applicants **
ENZYMASTER (NINGBO) BIO-ENGINEERING CO., LTD.
North Century Avenue, (6-21) - (6-27), Block 015 333
Ningbo, Zhejiang 315000, CN
Inventors
YANG, Xinhang
333 North Century Avenue, (6-21) - (6-27), Block 015
Ningbo, Zhejiang 315000, CN
ZHAO, Xin
333 North Century Avenue, (6-21) - (6-27), Block 015
Ningbo, Zhejiang 315000, CN
LUO, Xiao
333 North Century Avenue, (6-21) - (6-27), Block 015
Ningbo, Zhejiang 315000, CN
XIE, Hongmei
333 North Century Avenue, (6-21) - (6-27), Block 015
Ningbo, Zhejiang 315000, CN
HONG, Zhongjie
333 North Century Avenue, (6-21) - (6-27), Block 015
Ningbo, Zhejiang 315000, CN
DAI, Yixin
333 North Century Avenue, (6-21) - (6-27), Block 015
Ningbo, Zhejiang 315000, CN
SUN, Fenshuai
333 North Century Avenue, (6-21) - (6-27), Block 015
Ningbo, Zhejiang 315000, CN
ZHAO, Junxia
North Century Avenue, (6-21) - (6-27), Block 015 333
Ningbo, Zhejiang 315000, CN
HE, Kuifang
(6-21) - (6-27), Block 015 333 North Century Avenue
Ningbo, Zhejiang 315000, CN
ZHAO, Jialun
North Century Avenue, (6-21) - (6-27), Block 015 333
Ningbo, Zhejiang 315000, CN
CHEN, Haibin
(6-21) - (6-27), Block 015 333 North Century Avenue
Ningbo, Zhejiang 315000, CN
Priority Data
202310640536.9
31.05.2023
CN
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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International Searching Authority |
CNIPA
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| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
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| * | |
| Entry into National Phase under |
Chapter I
* |
| Translation |
|
Recalculate
* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 969 | |
| EPO | Filing, Examination | 6505 | |
| Japan | Filing | 533 | |
| South Korea | Filing | 575 | |
| USA | Filing, Examination | 4435 |
Total: 13017 USD
Abstract[English]
Provided are improved engineered halohydrin dehalogenases that can tolerate high substrate concentrations and has high substrate specificity and activity. The engineered halohydrin dehalogenase is capable of converting (R) -styrene oxide from racemic styrene oxide to (S) -4-phenyl-2-oxazolidinone; and resolving racemic styrene oxide to obtain (S)-styrene oxide in high purity.[French]
La présente invention concerne des halohydrines déhalogénases améliorées qui peuvent tolérer des concentrations élevées de substrat et qui présentent une spécificité et une activité de substrat élevées. L'halohydrine déhalogénase modifiée peut convertir l'oxyde de styrène (R) de l'oxyde de styrène racémique en (S) -4-phényl-2-oxazolidinone ; et résoudre l'oxyde de styrène racémique pour obtenir de l'oxyde de (S)-styrène d'une grande pureté.