WO2024244953 - A REACTION PROCESS AND BIOCATALYST FOR PREPARING ENANTIOPURE (S) -4-PHENYL-2-OXAZOLIDINONE
National phase entry is expected:
Publication Number
WO/2024/244953
Publication Date
05.12.2024
International Application No.
PCT/CN2024/092820
International Filing Date
13.05.2024
Title **
[English]
A REACTION PROCESS AND BIOCATALYST FOR PREPARING ENANTIOPURE (S) -4-PHENYL-2-OXAZOLIDINONE
[French]
PROCÉDÉ DE RÉACTION ET BIOCATALYSEUR POUR LA PRÉPARATION DE (S) -4-PHÉNYL-2-OXAZOLIDINONE ÉNANTIOPURE
Applicants **
ENZYMASTER (NINGBO) BIO-ENGINEERING CO., LTD.
Inventors
YANG, Xinhang
ZHAO, Xin
LUO, Xiao
XIE, Hongmei
HONG, Zhongjie
DAI, Yixin
SUN, Fenshuai
ZHAO, Junxia
HE, Kuifang
ZHAO, Jialun
CHEN, Haibin
Priority Data
202310640536.9
31.05.2023
CN
Application details
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International Searching Authority |
CNIPA
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 1606 | |
| EPO | Filing, Examination, Granting | 11712 | |
| Japan | Filing, Examination, Granting | 2075 | |
| South Korea | Filing, Examination, Granting | 1831 | |
| USA | Filing, Examination, Granting | 6540 |
Total:
23,764
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
Provided are improved engineered halohydrin dehalogenases that can tolerate high substrate concentrations and has high substrate specificity and activity. The engineered halohydrin dehalogenase is capable of converting (R) -styrene oxide from racemic styrene oxide to (S) -4-phenyl-2-oxazolidinone; and resolving racemic styrene oxide to obtain (S)-styrene oxide in high purity.[French]
La présente invention concerne des halohydrines déhalogénases améliorées qui peuvent tolérer des concentrations élevées de substrat et qui présentent une spécificité et une activité de substrat élevées. L'halohydrine déhalogénase modifiée peut convertir l'oxyde de styrène (R) de l'oxyde de styrène racémique en (S) -4-phényl-2-oxazolidinone ; et résoudre l'oxyde de styrène racémique pour obtenir de l'oxyde de (S)-styrène d'une grande pureté.