WO2023246680 - ACTIVATORS OF COAGULATION FACTOR X AND FORMULATIONS THEREOF FOR TREATING BLEEDING DISORDERS

National phase entry:
Publication Number WO/2023/246680
Publication Date 28.12.2023
International Application No. PCT/CN2023/100987
International Filing Date 19.06.2023
Title **
[English] ACTIVATORS OF COAGULATION FACTOR X AND FORMULATIONS THEREOF FOR TREATING BLEEDING DISORDERS
[French] ACTIVATEURS DU FACTEUR DE COAGULATION X ET FORMULATIONS DE CEUX-CI POUR LE TRAITEMENT DE TROUBLES HÉMORRAGIQUES
Applicants **
JIANGSU BIOJETAY BIOTECHNOLOGY CO.,LTD.
Inventors
ZHOU, Zan
WANG, Xiaomin
WANG, Bingzhang
LIU, Junyong
Priority Data
PCT/CN2022/099820   20.06.2022   CN
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting5533
EPO Filing, Examination, Granting125197
Japan Filing, Examination, Granting4903
South Korea Filing, Examination, Granting9198
USA Filing, Examination, Granting25790
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Total: 170,621

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Abstract[English] Provided herein are compositions (e.g., pharmaceutical compositions) of coagulation factor X activator (FX activator, e.g., RVV-X) comprising sucrose, histidine, polysorbate 20, and mannitol, and uses of FX activators (e.g., RVV-X) or compositions (e.g., pharmaceutical compositions) thereof for treating a bleeding disorder (e.g., hemophilia) in an individual (e.g., human).[French] L'invention concerne des compositions (par exemple, des compositions pharmaceutiques) de l'activateur du facteur de coagulation X (activateur FX, par ex., RVV-X) comprenant du saccharose, de l'histidine, du polysorbate 20 et du mannitol, ainsi que des utilisations d'activateurs FX (par ex., RVV-X) ou de compositions (par ex., des compositions pharmaceutiques) de ceux-ci pour traiter un trouble de saignement (par ex., l'hémophilie) chez un individu (par ex., un être humain).

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