WO2024001593 - ENGINEERED KETOREDUCTASES FOR THE PREPARATION OF CHIRAL ALCOHOLS AND METHODS THEREOF

National phase entry is expected:
Publication Number WO/2024/001593
Publication Date 04.01.2024
International Application No. PCT/CN2023/094905
International Filing Date 17.05.2023
Title **
[English] ENGINEERED KETOREDUCTASES FOR THE PREPARATION OF CHIRAL ALCOHOLS AND METHODS THEREOF
[French] CÉTORÉDUCTASES MODIFIÉES POUR LA PRÉPARATION D'ALCOOLS CHIRAUX ET PROCÉDÉS ASSOCIÉS
Applicants **
ENZYMASTER (NINGBO) BIO-ENGINEERING CO., LTD. North Century Avenue, (6-21) - (6-27), Block 015 333 Ningbo, Zhejiang 315000, CN
Inventors
CHEN, Haibin 333 North Century Avenue, (6-21) - (6-27), Block 015 Ningbo, Zhejiang 315000, CN
LIANG, Yafang 333 North Century Avenue, (6-21) - (6-27), Block 015 Ningbo, Zhejiang 315000, CN
ZHANG, Yingxin 333 North Century Avenue, (6-21) - (6-27), Block 015 Ningbo, Zhejiang 315000, CN
XIA, Zekun 333 North Century Avenue, (6-21) - (6-27), Block 015 Ningbo, Zhejiang 315000, CN
ZHOU, Ameng 333 North Century Avenue, (6-21) - (6-27), Block 015 Ningbo, Zhejiang 315000, CN
BOCOLA, Marco 333 North Century Avenue, (6-21) - (6-27), Block 015 Ningbo, Zhejiang 315000, CN
XU, Junpeng 333 North Century Avenue, (6-21) - (6-27), Block 015 Ningbo, Zhejiang 315000, CN
LUO, Xiao 333 North Century Avenue, (6-21) - (6-27), Block 015 Ningbo, Zhejiang 315000, CN
MAO, Jingxian 333 North Century Avenue, (6-21) - (6-27), Block 015 Ningbo, Zhejiang 315000, CN
HONG, Ruimei 333 North Century Avenue, (6-21) - (6-27), Block 015 Ningbo, Zhejiang 315000, CN
WU, Xinwei 333 North Century Avenue, (6-21) - (6-27), Block 015 Ningbo, Zhejiang 315000, CN
SUN, Lei 333 North Century Avenue, (6-21) - (6-27), Block 015 Ningbo, Zhejiang 315000, CN
DAI, Yixin 333 North Century Avenue, (6-21) - (6-27), Block 015 Ningbo, Zhejiang 315000, CN
WANG, Songxue 333 North Century Avenue, (6-21) - (6-27), Block 015 Ningbo, Zhejiang 315000, CN
PENG, Qinli 333 North Century Avenue, (6-21) - (6-27), Block 015 Ningbo, Zhejiang 315000, CN
Priority Data
202210753932.8   29.06.2022   CN
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Quotation for National Phase entry

Country StagesTotal
China Filing1196
EPO Filing, Examination6692
Japan Filing593
South Korea Filing575
USA Filing, Examination6910
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Total: 15966

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Abstract[English] Provided is an engineered ketoreductase polypeptide capable of preparing chiral alcohols, especially for catalyzing the reduction of ethyl 4-chloroacetoacetate to produce ethyl (R) -4-chloro-3-hydroxybutyrate. The polypeptides has high catalytic activity, high stereoselectivity, better thermal stability and solvent tolerance; the reaction process using engineered ketoreductase polypeptides may have a substrate loading of up to 426 g/L and a conversion of up to 99%.[French] La présente invention concerne un polypeptide de cétoréductase modifié, capable de préparer des alcools chiraux, en particulier de catalyser la réduction du 4-chloroacétate d'éthyle pour produire du (R) -4-chloro-3-hydroxybutyrate d'éthyle. Les polypeptides ont une activité catalytique élevée, une stéréosélectivité élevée, une meilleure stabilité thermique et une meilleure tolérance aux solvants; le processus de réaction utilisant des polypeptides de cétoréductase modifiés peut présenter une charge de substrat allant jusqu'à 426 g/L et un taux de conversion allant jusqu'à 99 %.
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