WO2023088077 - BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF PREGABALIN INTERMEDIATES
National phase entry:
Publication Number
WO/2023/088077
Publication Date
25.05.2023
International Application No.
PCT/CN2022/128468
International Filing Date
30.10.2022
Title **
[English]
BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF PREGABALIN INTERMEDIATES
[French]
BIOCATALYSEURS ET PROCÉDÉS POUR LA SYNTHÈSE D'INTERMÉDIAIRES DE PRÉGABALINE
Applicants **
ENZYMASTER (NINGBO) BIO-ENGINEERING CO., LTD.
(6-21) - (6-27), Block 015
333 North Century Avenue
Ningbo, Zhejiang 315000, CN
Inventors
ZHANG, Yingxin
(6-21) - (6-27), Block 015
333 North Century Avenue
Ningbo, Zhejiang 315000, CN
CHEN, Haibin
(6-21) - (6-27), Block 015
333 North Century Avenue
Ningbo, Zhejiang 315000, CN
BOCOLA, Marco
(6-21) - (6-27), Block 015
333 North Century Avenue
Ningbo, Zhejiang 315000, CN
CAI, Baoqin
(6-21) - (6-27), Block 015
333 North Century Avenue
Ningbo, Zhejiang 315000, CN
ZHANG, Zhaoqi
(6-21) - (6-27), Block 015
333 North Century Avenue
Ningbo, Zhejiang 315000, CN
LUO, Xiao
(6-21) - (6-27), Block 015
333 North Century Avenue
Ningbo, Zhejiang 315000, CN
JI, Yaoyao
(6-21) - (6-27), Block 015
333 North Century Avenue
Ningbo, Zhejiang 315000, CN
ZHANG, Chengxiao
(6-21) - (6-27), Block 015
333 North Century Avenue
Ningbo, Zhejiang 315000, CN
HONG, Ruimei
(6-21) - (6-27), Block 015
333 North Century Avenue
Ningbo, Zhejiang 315000, CN
Priority Data
202111381310.9
21.11.2021
CN
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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International Searching Authority |
CNIPA
* |
| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Translation |
|
Recalculate
* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 1411 | |
| EPO | Filing, Examination | 9258 | |
| Japan | Filing | 591 | |
| South Korea | Filing | 575 | |
| USA | Filing, Examination | 6910 |
Total: 18745 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
Provided is an engineered polypeptide capable of catalyzing the asymmetric hydrolysis of 3-isobutylglutarimide to generate (R) - (-) -3- (carbamoylmethyl) -5-methylhexanoic acid. The engineered polypeptide has high stereoselectivity, high catalytic activity, good process stability and thermal stability, and tolerance to high product concentrations, and has good prospects for industrial applications.[French]
L'invention concerne un polypeptide modifié capable de catalyser l'hydrolyse asymétrique de 3-isobutylglutarimide pour générer de l'acide (R)- (-)-3-(carbamoylméthyle)-5-méthylhexanoïque. Le polypeptide modifié possède une stéréosélectivité élevée, une activité catalytique élevée, une bonne stabilité durant le processus et une bonne stabilité thermique, ainsi qu'une tolérance à des concentrations élevées de produits, et offre de bonnes perspectives d'applications industrielles.