WO2023024055 - PREPARATION METHOD OF POLYVINYL ALCOHOL-ACRYLAMIDE -AGAROSE HYDROGELWITH HIGH MECHANICAL STRENGTH
National phase entry is expected:
Publication Number
WO/2023/024055
Publication Date
02.03.2023
International Application No.
PCT/CN2021/114907
International Filing Date
27.08.2021
Title **
[English]
PREPARATION METHOD OF POLYVINYL ALCOHOL-ACRYLAMIDE -AGAROSE HYDROGELWITH HIGH MECHANICAL STRENGTH
[French]
PROCÉDÉ DE PRÉPARATION D'HYDROGEL D'ALCOOL POLYVINYLIQUE-ACRYLAMIDE-AGAROSE À HAUTE RÉSISTANCE MÉCANIQUE
Applicants **
DALIAN UNIVERSITY OF TECHNOLOGY
No. 2 Linggong Road
Dalian, Liaoning 116024, CN
Inventors
ZHANG, Wei
Dalian University of Technology
No. 2 Linggong Road
Dalian, Liaoning 116024, CN
LI, Jinming
Dalian University of Technology
No. 2 Linggong Road
Dalian, Liaoning 116024, CN
LI, Heng
Dalian University of Technology
No. 2 Linggong Road
Dalian, Liaoning 116024, CN
WU, Chengwei
Dalian University of Technology
No. 2 Linggong Road
Dalian, Liaoning 116024, CN
Application details
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International Searching Authority |
CNIPA
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 899 | |
| EPO | Filing, Examination | 7051 | |
| Japan | Filing | 589 | |
| South Korea | Filing | 482 | |
| USA | Filing, Examination | 2710 |
Total: 11731 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
Provided is a method for preparing polyvinyl alcohol-acrylamide-agarose hydrogel with high mechanical strength. Polyvinyl alcohol and acrylamide are used as matrix materials, and a small amount of agarose is added. The acrylamide molecules form the first network on the application of a chemical cross linking agent. The polyvinyl alcohol molecules physically crosslink with each other in freeze-thawing cycle and form the second network. Agarose can form hydrogen bonds with the molecular chains of polyvinyl alcohol and acrylamide, which further improves the mechanical strength of the hydrogel. Additionally, the introduction of agarose enables the hydrogel to adhere chondrocyte and promote chondrocyte proliferation. The hydrogel prepared by this method has the potential to be applied in articular cartilage replacement.[French]
L'invention concerne un procédé de préparation d'hydrogel d'alcool polyvinylique-acrylamide-agarose à haute résistance mécanique. L'alcool polyvinylique et l'acrylamide sont utilisés comme matériaux matriciels, et une petite quantité d'agarose est ajoutée. Les molécules d'acrylamide forment le premier réseau sur l'application d'un agent de réticulation chimique. Les molécules d'alcool polyvinylique se réticulent physiquement l'une avec l'autre dans un cycle de congélation-décongélation et forment le second réseau. L'agarose peut former des liaisons hydrogène avec les chaînes moléculaires d'alcool polyvinylique et d'acrylamide, ce qui améliore en outre la résistance mécanique de l'hydrogel. De plus, l'introduction d'agarose permet à l'hydrogel d'adhérer à un chondrocyte et de favoriser la prolifération des chondrocytes. L'hydrogel préparé par ce procédé a le potentiel d'être appliqué dans le remplacement du cartilage articulaire.