WO2024229534 - A METHOD TO SOLUBILISE POLYGLUTAMINE AGGREGATES IN NEUROLOGICAL DISEASE
National phase entry is expected:
Publication Number
WO/2024/229534
Publication Date
14.11.2024
International Application No.
PCT/AU2024/050467
International Filing Date
10.05.2024
Title **
[English]
A METHOD TO SOLUBILISE POLYGLUTAMINE AGGREGATES IN NEUROLOGICAL DISEASE
[French]
MÉTHODE DE SOLUBILISATION D'AGRÉGATS DE POLYGLUTAMINE DANS LE CAS D'UNE MALADIE NEUROLOGIQUE
Applicants **
BRANSGROVE, Anthony
7-9 MERRIWA STREET,
Gordon, New South Wales 2072, AU
Inventors
BRANSGROVE, Anthony
7-9 MERRIWA STREET,
Gordon, New South Wales 2072, AU
Priority Data
2023901428
11.05.2023
AU
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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International Searching Authority |
IP Australia
* |
| Applicant's Legal Status |
Natural Person
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| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
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| Translation |
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Recalculate
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 1547 | |
| EPO | Filing, Examination | 8460 | |
| Japan | Filing | 597 | |
| South Korea | Filing | 575 | |
| USA | Filing, Examination | 4710 |
Total: 15889 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
The present invention relates to a process for the solubilisation and disaggregation of polyglutamine [poly(Q)] peptides using nucleic acids and nucleic acid analogues. The process relies on the discovery that polyadenine will bind to poly(Q) in a specific manner. Which in turn indicates that adenine can bind in a complementary manner to the cis conformed backbone of any peptide or protein through an alignment of their polar groups. The cis backbone structure then, appears able to mimic the part played by uracil or thymine. This is a novel if not revolutionary view of the binding potential of adenine nucleotides and no instance of this mode of binding has previously been identified or communicated.[French]
La présente invention concerne une méthode de solubilisation et de désagrégation de peptides de polyglutamine [poly(Q)] à l'aide d'acides nucléiques et d'analogues d'acides nucléiques. Le procédé repose sur la découverte que la polyadénine se lie à poly(Q) d'une manière spécifique. Ce qui à son tour indique que l'adénine peut se lier de manière complémentaire au squelette cis conforme de n'importe quel(le) peptide ou protéine par l'intermédiaire d'un alignement de leurs groupes polaires. La structure de squelette cis apparaît alors apte à imiter le rôle joué par l'uracile ou la thymine. Ceci est une vision nouvelle, voire révolutionnaire, du potentiel de liaison des nucléotides d'adénine et aucune instance de ce mode de liaison n'a été précédemment identifiée ou communiquée.