WO2023168499 - A METHOD OF PRECISION TREATMENT
National phase entry:
Publication Number
WO/2023/168499
Publication Date
14.09.2023
International Application No.
PCT/AU2023/050326
International Filing Date
21.04.2023
Title **
[English]
A METHOD OF PRECISION TREATMENT
[French]
PROCÉDÉ DE TRAITEMENT DE PRÉCISION
Applicants **
POLYGENRX PTY LTD
18 Schroder Avenue
Waratah, New South Wales 2298, AU
Inventors
CAIRNS, Murray
18 Schroder Avenue
Waratah, New South Wales 2298, AU
REAY, William
8 Karloo Street, Shortland, NSW, 2307, AU
Priority Data
2022900558
08.03.2022
AU
Application details
| Total Number of Claims/PCT | * |
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International Searching Authority |
IP Australia
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 1073 | |
| EPO | Filing, Examination | 6704 | |
| Japan | Filing | 596 | |
| South Korea | Filing | 575 | |
| USA | Filing, Examination | 2710 |
Total: 11658 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
Disclosed herein are methods for the precision treatment of human subjects with a complex disorder or disorders, comprising identifying directional anchors that constitute either therapeutic agents or therapeutic targets to treat the disorder and quantifying common variant enrichment amongst genes biologically annotated as linked to the directional anchor. As described herein, the quantification of common variant enrichment amongst the genes biologically linked to a directional anchor provides a means of summating an individual's exposure burden to genetic risk variants that is potentially treatable by a pharmacological agent or intervention that is related to a directional anchor. In other words, the quantified burden of genetic risk amongst genes linked to a directional anchor may inform individuals more sensitive to treatment by that intervention or an intervention which targets it.[French]
L'invention divulgue des procédés pour le traitement de précision de sujets humains avec un trouble ou des troubles complexes, comprenant l'identification d'ancrages directionnels qui constituent des agents thérapeutiques ou des cibles thérapeutiques pour traiter le trouble et la quantification d'un enrichissement de variant commun parmi des gènes annotés biologiquement comme liés à l'ancrage directionnel. Selon la présente invention, la quantification d'un enrichissement de variant commun parmi les gènes liés biologiquement à un ancrage directionnel fournit un moyen de sommation de la charge d'exposition d'un individu à des variants de risque génétique qui peuvent potentiellement être traités par un agent pharmacologique ou une intervention qui est associée à un ancrage directionnel. En d'autres termes, la charge quantifiée du risque génétique parmi les gènes liés à un ancrage directionnel peut informer des individus plus sensibles au traitement par cette intervention ou une intervention qui la cible.