WO2024180512 - PROCESS FOR PREPARATION OF DUAL GIP/GLP-1 PEPTIDES HAVING CONTROLLED PARTICLE SIZE

National phase entry:
Publication Number WO/2024/180512
Publication Date 06.09.2024
International Application No. PCT/IB2024/051967
International Filing Date 29.02.2024
Title **
[English] PROCESS FOR PREPARATION OF DUAL GIP/GLP-1 PEPTIDES HAVING CONTROLLED PARTICLE SIZE
[French] PROCESSUS DE PRÉPARATION DE PEPTIDES DOUBLES GIP/GLP-1 AYANT UNE TAILLE DE PARTICULE CONTRÔLÉE
Applicants **
ASSIA CHEMICAL INDUSTRIES LTD.
Inventors
BAREL, Offir
MASARWA, Abed
LAPIDO, Polina
Priority Data
63/449,378   02.03.2023   US
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting2809
EPO Filing, Examination, Granting19024
Japan Filing, Examination, Granting2891
South Korea Filing, Examination, Granting3707
USA Filing, Examination, Granting11340
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Total: 39,771

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Abstract[English] The present disclosure relates to processes for preparation of a peptide powder, and the preparation of peptide particles, for example a Dual GIP/GLP-1 peptide such as Tirzepatide. More specifically, the disclosure relates to a process comprising lyophilizing a solution comprising the peptide; and particle size reduction of the obtained lyophilizate. The disclosure further relates to Dual GIP/GLP-1 peptides, particularly Tirzepatide, obtainable by said process and its use in medicine and cosmetic treatment.[French] La présente divulgation concerne des processus de préparation d'une poudre peptidique, et la préparation de particules peptidiques, par exemple un peptide double GIP/GLP-1 tel que le Tirzepatide. Plus spécifiquement, la divulgation concerne un processus comprenant la lyophilisation d'une solution comprenant le peptide ; et la réduction de la taille des particules du lyophilisat obtenu. La divulgation concerne en outre des peptides doubles GIP/GLP-1, en particulier le Tirzepatide, pouvant être obtenus par ledit processus et leur utilisation en médecine et dans un traitement cosmétique.