WO2023148646 - MIRROR-IMAGE SELECTION OF L-NUCLEIC ACID APTAMERS
National phase entry:
Publication Number
WO/2023/148646
Publication Date
10.08.2023
International Application No.
PCT/IB2023/050908
International Filing Date
02.02.2023
Title **
[English]
MIRROR-IMAGE SELECTION OF L-NUCLEIC ACID APTAMERS
[French]
SÉLECTION D'IMAGE MIROIR D'APTAMÈRES D'ACIDE L-NUCLÉIQUE
Applicants **
TSINGHUA UNIVERSITY
Inventors
ZHU, Ting
CHEN, Ji
Priority Data
63/306,139
03.02.2022
US
63/311,092
17.02.2022
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
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| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| 译文 |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2762 | |
| EPO | Filing, Examination, Granting | 17576 | |
| Japan | Filing, Examination, Granting | 2690 | |
| South Korea | Filing, Examination, Granting | 3281 | |
| USA | Filing, Examination, Granting | 7940 |
Total:
34,249
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
A method for screening L-nucleic acid aptamers for binding to a target molecule is disclosed. The method comprises: (a) contacting the plurality of L-nucleic acid aptamers with the target molecule under conditions that selectively capture target-bound L-nucleic acid aptamers from the plurality of L- nucleic acid aptamers; (b) amplifying L-nucleic acid aptamers of the target-bound L-nucleic acid aptamers to generate amplified, double-stranded L-nucleic acid oligonucleotides; and (c) isolating amplified double stranded L-nucleic acid oligonucleotides using an electrophoresis based method, thereby screening the plurality of L-nucleic acid aptamers.[French]
L'invention concerne un procédé de criblage d'aptamères d'acide L-nucléique pour identifier la liaison à une molécule cible. Le procédé comprend les étapes consistant à : (a) mettre en contact la pluralité d'aptamères d'acide L-nucléique avec la molécule cible dans des conditions de capture sélective d'aptamères d'acide L-nucléique liés à une cible à partir de la pluralité d'aptamères d'acide L-nucléique ; (b) amplifier des aptamères d'acide L-nucléique des L-aptamères d'acide nucléique liés à une cible pour générer des oligonucléotides d'acide L-nucléique double brin amplifiés ; et (c) isoler des oligonucléotides d'acide L-nucléique double brin amplifiés à l'aide d'un procédé basé sur l'électrophorèse, ce qui permet de cribler la pluralité d'aptamères d'acide L-nucléique.