WO2023037268 - LINKERS FOR USE IN ANTIBODY DRUG CONJUGATES

National phase entry:
Publication Number WO/2023/037268
Publication Date 16.03.2023
International Application No. PCT/IB2022/058428
International Filing Date 07.09.2022
Title [English] LINKERS FOR USE IN ANTIBODY DRUG CONJUGATES [French] LIEURS DESTINÉS À ÊTRE UTILISÉS DANS DES CONJUGUÉS ANTICORPS-MÉDICAMENT
Applicants ** ORUM THERAPEUTICS, INC. 2F, 281-25, Munji-ro Yuseong-gu Daejeon 34050, KR
Inventors ** FISHKIN, Nathan Orum Therapeutics, Ipsen Innovation Center/Biolabs 650 East Kendall St. Cambridge, Massachusetts 02142, US BAI, Chen Orum Therapeutics, Ipsen Innovation Center/Biolabs 650 East Kendall St. Cambridge, Massachusetts 02142, US TAKROURI, Khuloud Orum Therapeutics, Ipsen Innovation Center/Biolabs 650 East Kendall St. Cambridge, Massachusetts 02142, US PARK, Peter U. Orum Therapeutics, Ipsen Innovation Center/Biolabs 650 East Kendall St. Cambridge, Massachusetts 02142, US
Priority Data 63/241,914  08.09.2021  US 63/293,591  23.12.2021  US 63/351,639  13.06.2022  US 63/374,282  01.09.2022  US
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Country Stages Total
China Filing 6105
EPO Filing, Examination 77550
Japan Filing 574
South Korea Filing 675
USA Filing, Examination 27885
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Abstract [English] The present disclosure provides traceless linkers, which can link an inducer of protein-protein interaction to a cell binding agent. Also provided are compositions comprising the linked compounds. The compounds and compositions are useful for treating diseases such as cancer in subjects in need thereof. [French] La présente divulgation concerne des lieurs sans trace, qui peuvent lier un inducteur d'interaction protéine-protéine à un agent de liaison cellulaire. La divulgation concerne également des compositions comprenant les composés liés. Les composés et les compositions sont utiles pour traiter des maladies telles que le cancer chez des sujets en ayant besoin.