Publication Number
WO/2023/037184
Publication Date
16.03.2023
International Application No.
PCT/IB2022/057787
International Filing Date
19.08.2022
Title
[English]
NOVEL PROCESS FOR THE PREPARATION OF BILASTINE AND INTERMEDIATES THEREOF
[French]
NOUVEAU PROCÉDÉ DE PRÉPARATION DE BILASTINE ET SES INTERMÉDIAIRES
Applicants **
BIOPHORE INDIA PHARMACEUTICALS PVT. LTD
Plot#92; 1-98/2/92, Kavuri Hills – Phase II, Jubilee Hills, Hyderabad, Telangana,
Hyderabad 500033, IN
Inventors **
PULLAGURLA, Manik Reddy
Plot#92; 1-98/2/92, Kavuri Hills – Phase II, Jubilee Hills, Hyderabad, Telangana,
Hyderabad 500033, IN
PITTA, Bhaskar Reddy
Plot#92; 1-98/2/92, Kavuri Hills – Phase II, Jubilee Hills, Hyderabad, Telangana,
Hyderabad 500033, IN
RANGISETTY, Jagadeesh Babu
Plot#92; 1-98/2/92, Kavuri Hills – Phase II, Jubilee Hills, Hyderabad, Telangana,
Hyderabad 500033, IN
Priority Data
202141037570
19.08.2021
IN
Application details
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Abstract
[English]
The present invention relates to a novel process for the preparation of 2-[4-[2-[4-[1-(2-ethoxyethyl) benzimidazol-2-yl] piperidin-1-yl] ethyl] phenyl]-2-methyl propionic acid (I). It further relates to a process for the purification of Bilastine (I), is having purity greater than 99.0% by High performance liquid chromatography (HPLC).
[French]
La présente invention concerne un nouveau procédé de préparation d'acide 2-[4-[2-[4-[1-(2-éthoxyéthyl)benzimidazol-2-yl]pipéridin-1-yl]éthyl]phényl]-2-méthyl-propionique (I). L'invention concerne en outre un procédé de purification de bilastine (I), dont la pureté est supérieure à 99,0 % par chromatographie liquide haute performance (CLHP).