Publication Number
WO/2024/046937
Publication Date
07.03.2024
International Application No.
PCT/EP2023/073466
International Filing Date
28.08.2023
Title
[English]
THREOSE NUCLEIC ACID ANTISENSE OLIGONUCLEOTIDES AND METHODS THEREOF
[French]
OLIGONUCLÉOTIDES ANTISENS D'ACIDE NUCLÉIQUE DE THRÉOSE ET PROCÉDÉS ASSOCIÉS
Applicants **
F. HOFFMANN-LA ROCHE AG
Grenzacherstrasse 124
4070 Basel, CH
HOFFMANN-LA ROCHE INC.
Great Notch, 150 Clove Road
8th Floor, Suite 8 - Legal Department
Little Falls, New Jersey 07424, US
Inventors **
BASTIEN, Jessica Marine Aurore
c/o F. Hoffmann-La Roche AG
Grenzacherstrasse 124
4070 Basel, CH
BLEICHER, Konrad
c/o F. Hoffmann-La Roche AG
Grenzacherstrasse 124
4070 Basel, CH
CHRISTIANSEN, Helle
c/o Roche Innovation Center Copenhagen A/S
Fremtidsvej 3
2970 Hørsholm, DK
KIELPINSKI, Lukasz
c/o Roche Innovation Center Copenhagen A/S
Fremtidsvej 3
2970 Hørsholm, DK
KOLLER, Erich
c/o F. Hoffmann-La Roche AG
Grenzacherstrasse 124
4070 Basel, CH
LI, Meiling
c/o F. Hoffmann-La Roche AG
Grenzacherstrasse 124
4070 Basel, CH
OTTENEDER, Michael
c/o F. Hoffmann-La Roche AG
Grenzacherstrasse 124
4070 Basel, CH
SCHAEUBLIN, Adrian
c/o F. Hoffmann-La Roche AG
Grenzacherstrasse 124
4070 Basel, CH
SCHMIDT, Steffen
c/o Roche Innovation Center Copenhagen A/S
Fremtidsvej 3
2970 Hørsholm, DK
SEWING, Sabine
c/o F. Hoffmann-La Roche AG
Grenzacherstrasse 124
4070 Basel, CH
Priority Data
22192656.1
29.08.2022
EP
Application details
Recalculate
* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Abstract
[English]
Described are antisense oligonucleotides comprising one or more α-L-threofuranosyl (TNA) nucleosides linked to an adjacent nucleoside via a phosphodiester (PO) internucleoside linkage, as well as methods to modulate the properties of antisense oligonucleotides by the introduction of such TNA nucleosides. These are particularly applicable to antisense gapmer oligonucleotides.
[French]
L'invention concerne des oligonucléotides antisens comprenant un ou plusieurs nucléosides alpha-L-thréofuranosyl (TNA) liés à un nucléoside adjacent par l'intermédiaire d'une liaison internucléosidique phosphodiester (PO), ainsi que des procédés pour moduler les propriétés d'oligonucléotides antisens par l'introduction de tels nucléosides TNA. Ceux-ci sont particulièrement applicables aux oligonucléotides gapmers antisens.