WO2024052941 - IMPROVED PROCESS FOR THE PREPARATION OF VOCLOSPORIN
National phase entry:
Publication Number
WO/2024/052941
Publication Date
14.03.2024
International Application No.
PCT/IN2023/050851
International Filing Date
08.09.2023
Title **
[English]
IMPROVED PROCESS FOR THE PREPARATION OF VOCLOSPORIN
[French]
PROCÉDÉ AMÉLIORÉ POUR LA PRÉPARATION DE VOCLOSPORINE
Applicants **
DR. REDDY'S LABORATORIES LIMITED
Inventors
KATSINA, Tania
DE LUISI, Paola
MEEK, Graham
PALUMBO, Fabrizio
Priority Data
202241051571
09.09.2022
IN
Application details
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International Searching Authority |
IP India
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 1958 | |
| EPO | Filing, Examination, Granting | 11551 | |
| Japan | Filing, Examination, Granting | 1845 | |
| South Korea | Filing, Examination, Granting | 1470 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
21,564
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
The present invention provides an improved process for the preparation of Voclosporin, comprising oxidation of cyclosporin A acetate with potassium osmate and N-methyl morpholine N-oxide (NMMO) followed by sodium periodate and further conversion to Voclosporin. The present invention also covers crystallization of crude Voclosporin from acetone and heptane mixture.[French]
La présente invention concerne un procédé amélioré pour la préparation de voclosporine, comprenant l'oxydation de cyclosporine d'un acétate avec de l'osmate de potassium et du N-oxyde de N-méthylmorpholine (NMMO) suivie d'une périodate de sodium et une conversion supplémentaire en voclosporine. La présente invention concerne également la cristallisation de voclosporine brut à partir d'acétone et d'un mélange d'heptane.