WO2024018489 - METHOD FOR SELECTIVE REDUCTION OF DISULFIDE BONDS IN AN IMMUNOGLOBULIN
National phase entry is expected:
Publication Number
WO/2024/018489
Publication Date
25.01.2024
International Application No.
PCT/IN2023/050704
International Filing Date
21.07.2023
Title **
[English]
METHOD FOR SELECTIVE REDUCTION OF DISULFIDE BONDS IN AN IMMUNOGLOBULIN
[French]
PROCÉDÉ DE RÉDUCTION SÉLECTIVE DE LIAISONS DISULFURE DANS UNE IMMUNOGLOBULINE
Applicants **
DR. REDDY’S LABORATORIES LIMITED
Inventors
JAYARAMAN, Murali
SIGIREDDI, Indra Kumar
NANKAR, Sunil Ashok
NANATH, Maya
AGGARWAL, Lovisha
Priority Data
202241042144
22.07.2022
IN
Application details
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International Searching Authority |
IP India
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| 译文 |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 1956 | |
| EPO | Filing, Examination, Granting | 11576 | |
| Japan | Filing, Examination, Granting | 1970 | |
| South Korea | Filing, Examination, Granting | 1739 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
21,981
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
The present invention discloses a method for the selective reduction of disulfide bonds in an immunoglobulin composition. More specifically, the method disclosed in the current invention is capable of selectively reducing the inter-chain disulfide bond between the light and heavy chain of an immunoglobulin without the use of commonly used chemicals such as DTT, DTE, and β- mercaptoethanol. The method is advantageous over the existing methods as it eliminates the need of an additional purification step to remove the chemicals used for reduction, i.e., DTT, DTE, etc. before subjecting the immunoglobulin sample for further analyses such as LC-MS..[French]
La présente invention concerne un procédé de réduction sélective de liaisons disulfure dans une composition d'immunoglobuline. Plus particulièrement, le procédé décrit dans la présente invention peut réduire de manière sélective la liaison disulfure inter-chaîne entre la chaîne légère et lourde d'une immunoglobuline sans utilisation de produits chimiques couramment utilisés tels que DTT, DTE et β-mercaptoéthanol. Le procédé est avantageux par rapport aux procédés existants car il élimine le besoin d'une étape de purification supplémentaire pour éliminer les produits chimiques utilisés pour la réduction, c'est-à-dire, DTT, DTE, etc. avant de soumettre l'échantillon d'immunoglobuline à d'autres analyses telles que LC-MS.