WO2023012828 - METHOD TO PURIFY AN ANTIBODY COMPOSITION USING CATION EXCHANGE CHROMATOGRAPHY
National phase entry:
Publication Number
WO/2023/012828
Publication Date
09.02.2023
International Application No.
PCT/IN2022/050701
International Filing Date
04.08.2022
Title **
[English]
METHOD TO PURIFY AN ANTIBODY COMPOSITION USING CATION EXCHANGE CHROMATOGRAPHY
[French]
PROCÉDÉ DE PURIFICATION D'UNE COMPOSITION D'ANTICORPS AU MOYEN D'UNE CHROMATOGRAPHIE PAR ÉCHANGE DE CATIONS
Applicants **
DR. REDDY'S LABORATORIES LIMITED
Inventors
KUMAR M, Ram
APUORVA T, Roja
JAHAGIRDAR, Kishore
Priority Data
202141035332
05.08.2021
IN
Application details
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International Searching Authority |
IP India
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| 译文 |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 1956 | |
| EPO | Filing, Examination, Granting | 11576 | |
| Japan | Filing, Examination, Granting | 2001 | |
| South Korea | Filing, Examination, Granting | 1805 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
22,078
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
The method disclosed in the current invention is used to purify an antibody from process and product related impurities. The method discloses the use of cation exchange chromatography for the reduction of impurities such as high molecular weight aggregates, protein-A leachates and host cell proteins from an antibody composition. The disclosed method leads to a significant reduction of HMW aggregates and other process related impurities without compromising on the recovery of the protein.[French]
La présente invention concerne un procédé permettant de purifier un anticorps des impuretés liées au procédé et au produit. Le procédé divulgue l'utilisation de la chromatographie par échange de cations pour la réduction des impuretés telles que les agrégats de poids moléculaire élevé (HMW), les lixiviats de protéine A et les protéines de cellules hôtes provenant d'une composition d'anticorps. Le procédé divulgué conduit à une réduction significative des agrégats HMW et d'autres impuretés liées au procédé sans compromettre la récupération de la protéine.