WO2026133273 - BACTERIAL VESICLES FOR RADIOTHERAPEUTIC DELIVERY OF BORON
National phase entry is expected:
Publication Number
WO/2026/133273
Publication Date
25.06.2026
International Application No.
PCT/IB2025/063238
International Filing Date
19.12.2025
Title **
[English]
BACTERIAL VESICLES FOR RADIOTHERAPEUTIC DELIVERY OF BORON
[French]
VÉSICULES BACTÉRIENNES POUR ADMINISTRATION RADIOTHÉRAPEUTIQUE DE BORE
Applicants **
ENGENEIC MOLECULAR DELIVERY PTY LTD
Inventors
BRAHMBHATT, Himanshu
MACDIARMID, Jennifer
Priority Data
63/737,100
20.12.2024
US
63/793,245
23.04.2025
US
Application details
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International Searching Authority |
IP Australia
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| 译文 |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2762 | |
| EPO | Filing, Examination, Granting | 19893 | |
| Japan | Filing, Examination, Granting | 2694 | |
| South Korea | Filing, Examination, Granting | 3275 | |
| USA | Filing, Examination, Granting | 7340 |
Total:
35,964
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Abstract[English]
Intact bacterial vesicles are highly effective for in vivo delivery of boron for radiotherapeutic purposes, as in boron neutron capture therapy. A compound comprising a boron isotope, such as boron-10 or boron-11, can be joined chemically to a fluorescent moiety to produce a molecule that can be loaded stably into bacterial vesicles, which when coated with an appropriately targeting bispecific antibody can deliver boron specifically into tumor cells in an amount enabling boron-mediated radiotherapy that eliminates tumor cells with minimal damage to adjacent normal cells.[French]
Les vésicules bactériennes intactes sont hautement efficaces pour l'administration in vivo de bore à des fins radiothérapeutiques, comme dans une thérapie par capture de neutrons de bore. Un composé comprenant un isotope de bore, tel que le bore 10 ou le bore 11, peut être joint chimiquement à une fraction fluorescente pour produire une molécule qui peut être chargée de manière stable dans des vésicules bactériennes, qui, lorsqu'elles sont revêtues d'un anticorps bispécifique ciblant de manière appropriée, peuvent libérer du bore spécifiquement dans des cellules tumorales en une quantité permettant une radiothérapie médiée par le bore qui élimine les cellules tumorales avec un endommagement minimal des cellules normales adjacentes.