WO2026133258 - INCREASED PRODUCTION OF ACETYL-COENZYME A AND DERIVED PRODUCTS IN YEAST
National phase entry is expected:
Publication Number
WO/2026/133258
Publication Date
25.06.2026
International Application No.
PCT/IB2025/063192
International Filing Date
18.12.2025
Title **
[English]
INCREASED PRODUCTION OF ACETYL-COENZYME A AND DERIVED PRODUCTS IN YEAST
[French]
PRODUCTION ACCRUE D'ACÉTYL-COENZYME A ET DE PRODUITS DÉRIVÉS DANS DES LEVURES
Applicants **
DANSTAR FERMENT AG
Inventors
HENNINGSEN, Brooks
WANG, Jian
Priority Data
63/736,111
19.12.2024
US
63/889,764
29.09.2025
US
Application details
| Total Number of Claims/PCT | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| 译文 |
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* The data is based on automatic recognition. Please verify and amend if necessary.
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 3207 | |
| EPO | Filing, Examination, Granting | 18915 | |
| Japan | Filing, Examination, Granting | 2660 | |
| South Korea | Filing, Examination, Granting | 3213 | |
| USA | Filing, Examination, Granting | 6990 |
Total:
34,985
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Abstract[English]
The present disclosure describes a recombinant yeast host cell having a first engineered metabolic pathway to convert fructose-6-phosphate (F-6-P) into acetyl-coenzyme A. The first engineered metabolic pathway comprises: a genetic modification for expressing a heterologous phosphoketolase capable of converting fructose-6-phosphate into erythrose-4-phosphate, and at least one genetic modification for decreasing native 6- phosphofructo-2-kinase activity classified under Enzyme Commission No. 2.7.1.105. Optionally, the recombinant yeast host cell comprises a second engineered metabolic pathway for convert acetyl-coA into a fermentation product. The present disclosure further describes a process for making a fermentation product. The process comprises contacting the recombinant yeast host cell described herein with a carbohydrate source under a condition allowing the conversion of at least a part of the carbohydrate into a fermentation product.[French]
La présente invention concerne une cellule hôte de levure recombinante ayant une première voie métabolique modifiée pour convertir le fructose-6-phosphate (F-6-P) en acétyl-coenzyme A. La première voie métabolique modifiée comprend : une modification génétique pour exprimer une phosphocétolase hétérologue pouvant convertir le fructose-6-phosphate en érythrose-4-phosphate, et au moins une modification génétique pour diminuer l'activité native de la 6-phosphofructo-2-kinase classée sous le numéro 2.7.1.105 selon la Commission des enzymes. Facultativement, la cellule hôte de levure recombinante comprend une seconde voie métabolique modifiée pour convertir l'acétyl-coA en un produit de fermentation. La présente divulgation concerne en outre un procédé de fabrication d'un produit de fermentation. Le procédé comprend la mise en contact de la cellule hôte de levure recombinante décrite ici avec une source de glucide dans une condition permettant la conversion d'au moins une partie du glucide en un produit de fermentation.