WO2026110119 - DOUBLE STRANDED RNAI AGENTS, COMPOSITIONS AND METHODS OF USE

National phase entry is expected:
Publication Number WO/2026/110119
Publication Date 28.05.2026
International Application No. PCT/IB2025/062012
International Filing Date 24.11.2025
Title **
[English] DOUBLE STRANDED RNAI AGENTS, COMPOSITIONS AND METHODS OF USE
[French] AGENTS D'ARNI DOUBLE BRIN, COMPOSITIONS ET PROCÉDÉS D'UTILISATION
Applicants **
NOVARTIS AG
Inventors
HAEMMIG, Stefan
HAGEN, Caitlin Jeanette
HUNZIKER, Juerg
TAN, Ge
TRAUGER, John Wesley
WEILER, Jan
Priority Data
63/724,671   25.11.2024   US
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting7756
EPO Filing, Examination, Granting74576
Japan Filing, Examination, Granting4131
South Korea Filing, Examination, Granting6095
USA Filing, Examination, Granting28690
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Total: 121,248
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Abstract[English] Disclosed are, inter alia, double stranded RNAi (dsRNAi) agents inhibiting expression of proprotein convertase subtilisin kexin 9 (PCSK9), for example, human PCSK9, compositions including the same, and methods of treatment using the same.[French] L'invention concerne, entre autres, des agents d'ARNi double brin (dsRNAi) inhibant l'expression de la proprotéine convertase subtilisine kexine 9 (PCSK9), par exemple, PCSK9 humain, des compositions les comprenant, et des procédés de traitement les utilisant.