WO2026105087 - VERDAZYL-BASED POLARIZING AGENTS AND USES IN DYNAMIC NUCLEAR POLARIZATION
National phase entry is expected:
Publication Number
WO/2026/105087
Publication Date
21.05.2026
International Application No.
PCT/IB2025/061750
International Filing Date
17.11.2025
Title **
[English]
VERDAZYL-BASED POLARIZING AGENTS AND USES IN DYNAMIC NUCLEAR POLARIZATION
[French]
AGENTS POLARISANTS À BASE DE VERDAZYLE ET UTILISATIONS EN POLARISATION NUCLÉAIRE DYNAMIQUE
Applicants **
THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
Inventors
MICHAELIS, Vladimir Konstantin
TYKWINSKI, Rik R.
MECKES, Jakob Andreas
SCHROEDER, Zachary William
SARKAR, Diganta
HOOPER, Riley Wayne
Priority Data
63/720,827
15.11.2024
US
Application details
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International Searching Authority |
CIPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| 译文 |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2459 | |
| EPO | Filing, Examination, Granting | 15297 | |
| Japan | Filing, Examination, Granting | 2339 | |
| South Korea | Filing, Examination, Granting | 2529 | |
| USA | Filing, Examination, Granting | 7340 |
Total:
29,964
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Abstract[English]
H DNP field profiles, and experiments to determine the nuclear build-up times were performed for verdazyl-nitroxide biradicals VerTEMPol and VerTEKol. These hybrid biradicals provide enhancements of up to 100-fold increased signal intensities, representing >104-fold time savings, and approximately 4 times as high as that of the nitroxide biradical TEKPol, a commonly used polarizing agent in the field.[French]
H DNP, et des expériences pour déterminer les temps d'accumulation nucléaire ont été réalisées pour des biradicaux de verdazyl-nitroxyde de VerTEMPol et de VerTEKol. Ces biradicaux hybrides fournissent des améliorations allant jusqu'à 100 fois des intensités de signal accrues, représentant > 104 fois d'économie de temps, et environ 4 fois plus élevées que celle du biradical nitroxyde TEKPol, un agent polarisant couramment utilisé dans le domaine.