WO2026094020 - PHTHALIC ACID AND VANILLIC ACID BASED CATIONIC LIPIDS

National phase entry is expected:
Publication Number WO/2026/094020
Publication Date 07.05.2026
International Application No. PCT/IB2025/061236
International Filing Date 04.11.2025
Title **
[English] PHTHALIC ACID AND VANILLIC ACID BASED CATIONIC LIPIDS
[French] LIPIDES CATIONIQUES À BASE D'ACIDE PHTALIQUE ET D'ACIDE VANILLIQUE
Applicants **
SANOFI PASTEUR INC.
Inventors
DASARI, Ramesh
DENG, Hongfeng
KARMAKAR, Saswata
LE, Crystal Si-Chuen
Priority Data
63/715,923   04.11.2024   US
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译文

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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting3881
EPO Filing, Examination, Granting15375
Japan Filing, Examination, Granting2155
South Korea Filing, Examination, Granting2071
USA Filing, Examination, Granting7140
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Total: 30,622
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Abstract[English] The present invention provides lipids of Formula (I) and (II) or subformulae thereof, or pharmaceutically acceptable salts thereof. Said lipids can be useful for the delivery and expression of mRNA and encoded protein, e.g. as a component of liposomal delivery vehicles, and accordingly can be useful for treating various diseases, disorders, and conditions, such as those associated with deficiency of one or more proteins. Compositions comprising lipid compounds of Formulae (I) and (II) and subformulae thereof, and mRNA encoding a peptide or protein may be administered to subjects in need thereof intramuscularly.[French] La présente invention concerne des lipides de formule (I) et (II) ou de sous-formules associées, ou des sels pharmaceutiquement acceptables de ceux-ci. Lesdits lipides peuvent être utiles pour l'administration et l'expression d'ARNm et de protéine codée, par exemple, en tant que constituant de véhicules d'administration liposomale, et peuvent par conséquent être utiles pour traiter divers maladies, troubles et affections, comme ceux associés à un déficit d'une ou de plusieurs protéines. Les compositions comprenant des composés lipidiques de formules (I) et (II) et de sous-formules associées, et un ARNm codant pour un peptide ou une protéine peuvent être administrées à des sujets en ayant besoin par voie intramusculaire.