WO2026038145 - IL-18 BINDING PROTEIN (IL-18BP) AND METHODS OF USING SAME

National phase entry is expected:
Publication Number WO/2026/038145
Publication Date 19.02.2026
International Application No. PCT/IB2025/058202
International Filing Date 12.08.2025
Title **
[English] IL-18 BINDING PROTEIN (IL-18BP) AND METHODS OF USING SAME
[French] PROTÉINE DE LIAISON À L'IL-18 (IL-18BP) ET SES MÉTHODES D'UTILISATION
Applicants **
AB2 BIO SA
Inventors
SCHIFFRIN, Eduardo
FILIPOVIC, Djordje
PORTMANN, Cyril
Priority Data
63/682,635   13.08.2024   US
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译文

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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting2767
EPO Filing, Examination, Granting17773
Japan Filing, Examination, Granting2677
South Korea Filing, Examination, Granting3139
USA Filing, Examination, Granting7740
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Total: 34,096
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Abstract[English] Provided herein are methods for preparing a subject for a conditioning treatment and/or reducing the toxicity of a conditioning treatment in a subject, wherein the subject is in need of a hematopoietic stem cell transplantation (HSCT) or bone marrow transplantation (BMT). Also provided are methods for increasing the recovery of a subject administered a HSCT or BMT. The subject in need of the HSCT or the BMT can, for example, be suffering from a disease or condition associated with increased inflammation prior to the HSCT or BMT.[French] L'invention concerne des méthodes de préparation d'un sujet pour un traitement de conditionnement et/ou de réduction de la toxicité d'un traitement de conditionnement chez un sujet, le sujet ayant besoin d'une transplantation de cellules souches hématopoïétiques (HSCT) ou d'une transplantation de moelle osseuse (BMT). L'invention concerne également des méthodes pour augmenter la récupération d'un sujet ayant reçu une HSCT ou une BMT. Le sujet ayant besoin d'une HSCT ou d'une BMT peut, par exemple, être souffrant d'une maladie ou d'une affection associée à une inflammation accrue avant la HSCT ou la BMT.