WO2026003796 - PRIMERS FOR SELECTIVELY AMPLIFYING GC-RICH SEQUENCES
National phase entry is expected:
Publication Number
WO/2026/003796
Publication Date
02.01.2026
International Application No.
PCT/IB2025/056549
International Filing Date
27.06.2025
Title **
[English]
PRIMERS FOR SELECTIVELY AMPLIFYING GC-RICH SEQUENCES
[French]
AMORCES POUR AMPLIFIER SÉLECTIVEMENT DES SÉQUENCES RICHES EN GC
Applicants **
DANA-FARBER CANCER INSTITUTE, INC.
Inventors
MAKRIGIORGOS, Gerassimos
DARBEHESHTI, Farzaneh
ZEGGAR, Hayet Radia
Priority Data
63/665,402
28.06.2024
US
63/793,730
24.04.2025
US
Application details
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| Number of Drawings | * |
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International Searching Authority |
USPTO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| 译文 |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 3959 | |
| EPO | Filing, Examination, Granting | 38321 | |
| Japan | Filing, Examination, Granting | 3390 | |
| South Korea | Filing, Examination, Granting | 4829 | |
| USA | Filing, Examination, Granting | 15360 |
Total:
65,859
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Abstract[English]
Primers are provided that are capable of (i) specifically hybridizing to a genomic DNA fragment comprising an adaptor, or an amplicon thereof, and (ii) selectively amplifying GC-rich sequences of a genome. The primers can be employed to interrogate the methylation status of multiple gene regulatory sequences in parallel, e.g., to identify aberrantly methylated or demethylated gene regulatory sequences on a global genomic scale. Methods that utilize, and compositions and kits that include, such primers are also described.[French]
L'invention concerne des amorces qui sont capables de (i) s'hybrider spécifiquement à un fragment d'ADN génomique comprenant un adaptateur, ou un amplicon de celui-ci, et (ii) amplifier sélectivement des séquences riches en GC d'un génome. Les amorces peuvent être utilisées pour interroger l'état de méthylation de multiples séquences régulatrices de gènes en parallèle, par exemple, pour identifier des séquences régulatrices de gènes méthylées ou déméthylées de manière aberrante sur une échelle génomique globale. L'invention concerne également des procédés qui utilisent, ainsi que des compositions et des kits qui comprennent de telles amorces.