WO2025202874 - GENETICALLY MODIFIED CELLS EXPRESSING GLP-1 RECEPTOR AGONIST

National phase entry is expected:
Publication Number WO/2025/202874
Publication Date 02.10.2025
International Application No. PCT/IB2025/053108
International Filing Date 24.03.2025
Title **
[English] GENETICALLY MODIFIED CELLS EXPRESSING GLP-1 RECEPTOR AGONIST
[French] CELLULES GÉNÉTIQUEMENT MODIFIÉES EXPRIMANT UN AGONISTE DU RÉCEPTEUR DE GLP-1
Applicants **
CRISPR THERAPEUTICS AG
Inventors
LIAO, Meichen
Priority Data
63/569,424   25.03.2024   US
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译文

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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting4750
EPO Filing, Examination, Granting72113
Japan Filing, Examination, Granting4285
South Korea Filing, Examination, Granting6410
USA Filing, Examination, Granting19190
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Total: 106,748
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Abstract[English] Disclosed herein include methods, compositions, and kits suitable for use in treating diseases or disorders related to insulin signaling. In some embodiments, the method comprises editing stem cells to express a GLP-1 receptor agonist. Also provided are compositions comprising the edited cells expressing a GLP-1 receptor agonist to treat, e.g., diabetes.[French] La divulgation concerne des procédés, des compositions et des kits appropriés pour être utilisés dans le traitement de maladies ou de troubles liés à la signalisation de l'insuline. Dans certains modes de réalisation, le procédé comprend la modification de cellules souches pour exprimer un agoniste du récepteur de GLP-1. La divulgation concerne également des compositions comprenant les cellules modifiées exprimant un agoniste du récepteur de GLP-1 pour traiter, par exemple, le diabète.