WO2025181704 - RT EDITING COMPOSITIONS AND METHODS
National phase entry is expected:
Publication Number
WO/2025/181704
Publication Date
04.09.2025
International Application No.
PCT/IB2025/052079
International Filing Date
26.02.2025
Title **
[English]
RT EDITING COMPOSITIONS AND METHODS
[French]
COMPOSITIONS ET PROCÉDÉS D'ÉDITION DE RT
Applicants **
CRISPR THERAPEUTICS AG
Inventors
FELLMANN, Christof
MIR, Aamir
GREWAL, Parbir Singh
JAYACHANDRAN, Megha
BARNHOUSE, Victoria
KADAM, Bhakti Narendra
CHEN, Victor
YUAN, Qichen
AJAMI, Nassim
LOAIZA, Cristian
FREEMAN, Benjamin Thomas
Priority Data
63/558,338
27.02.2024
US
63/649,882
20.05.2024
US
63/718,994
11.11.2024
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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| Number of Office Actions | * |
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International Searching Authority |
EPO
* |
| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
* |
| Type of Assignment |
The Standard Agent's Assignment
* |
| Applicant's Legal Status |
Legal Entity
* |
| * | |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Patent Delivery |
Send the Letters Patent by Courier
* |
| 译文 |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 6608 | |
| EPO | Filing, Examination, Granting | 112277 | |
| Japan | Filing, Examination, Granting | 4850 | |
| South Korea | Filing, Examination, Granting | 8204 | |
| USA | Filing, Examination, Granting | 35940 |
Total:
167,879
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Abstract[English]
Disclosed herein include methods, compositions, and kits suitable for use in gene editing. RT editing systems are provided herein comprising a fusion protein comprising a Cas9 nickase and a reverse transcriptase, and a template armed guide RNA (tagRNA) comprising from 5' to 3' a spacer sequence, a scaffold sequence, an editing template and a flap binding sequence. In some embodiments, the RT editing system further comprises an enhancer guide RNA (egRNA).[French]
L'invention concerne des procédés, des compositions et des kits appropriés pour une utilisation dans l'édition génomique. L'invention concerne des systèmes d'édition RT comprenant une protéine de fusion comprenant une nickase Cas9 et une transcriptase inverse, et un ARN guide armé d'un modèle (ARNtag) comprenant de 5' à 3' une séquence d'espaceur, une séquence d'échafaudage, un modèle d'édition et une séquence de liaison de lambeau. Dans certains modes de réalisation, le système d'édition de RT comprend en outre un ARN guide amplificateur (ARNeg).