WO2025177220 - ALTERNATIVE SELF-AMPLIFYING RNA

National phase entry is expected:
Publication Number WO/2025/177220
Publication Date 28.08.2025
International Application No. PCT/IB2025/051865
International Filing Date 21.02.2025
Title **
[English] ALTERNATIVE SELF-AMPLIFYING RNA
[French] ARN AUTO-AMPLIFICATEUR ALTERNATIF
Applicants **
SEQIRUS INC.
Inventors
CHANG, Cheng
PHILIP, Asha
Priority Data
63/556,098   21.02.2024   US
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting2786
EPO Filing, Examination, Granting20605
Japan Filing, Examination, Granting2647
South Korea Filing, Examination, Granting3192
USA Filing, Examination, Granting16710
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Total: 45,940
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Abstract[English] The present disclosure provides a self-amplifying RNA (sa-mRNA) comprising an open reading frame encoding a replicase or a non-structural protein 4 (nsP4) and an open reading frame encoding peptide or polypeptide, wherein the open reading frame encoding the peptide or polypeptide is co-expressed with the replicase or nsP4.[French] La présente divulgation concerne un ARN auto-amplificateur (ARNm-aa) comprenant un cadre de lecture ouvert codant pour une réplicase ou une protéine non structurale 4 (nsP4) et un cadre de lecture ouvert codant pour un peptide ou un polypeptide, le cadre de lecture ouvert codant pour le peptide ou le polypeptide étant co-exprimé avec la réplicase ou la nsP4.