WO2025146665 - SPACIO-TEMPORAL DETERMINATION OF INTRINSICALLY-DISORDERED POLYPEPTIDES AND INTERACTIONS THEREOF
National phase entry is expected:
Publication Number
WO/2025/146665
Publication Date
10.07.2025
International Application No.
PCT/IB2025/050093
International Filing Date
03.01.2025
Title **
[English]
SPACIO-TEMPORAL DETERMINATION OF INTRINSICALLY-DISORDERED POLYPEPTIDES AND INTERACTIONS THEREOF
[French]
DÉTERMINATION SPATIO-TEMPORELLE DE POLYPEPTIDES INTRINSÈQUEMENT DÉSORDONNÉS ET LEURS INTERACTIONS
Applicants **
PEPTONE LTD.
Inventors
TAMIOLA, Kamil
OWENS, Benjamin
FOERCH, Patrik
KUNZ, Patrick
INVERNIZZI, Michele
FISICARO, Carlo
PETERLE, Daniele
BOTTARO, Sandro
Priority Data
63/618,117
05.01.2024
US
Application details
| Total Number of Claims/PCT | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| 译文 |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 4884 | |
| EPO | Filing, Examination, Granting | 83742 | |
| Japan | Filing, Examination, Granting | 4591 | |
| South Korea | Filing, Examination, Granting | 7014 | |
| USA | Filing, Examination, Granting | 28990 |
Total:
129,221
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Abstract[English]
Provided herein are methods for interrogating interactions between a binding molecule and a polypeptide of interest using hydrogen-deuterium exchange mass spectrometry, optionally in combination with in silico modelling of the binding interaction between the binding molecule and the polypeptide. The polypeptides of interest that are interrogated in a disordered domain include, without limitation, androgen receptor polypeptides, alpha-synuclein polypeptides, p27 polypeptides, c-myc polypeptides, and Tau polypeptides. Further described herein are enrichment of molecules that bind to a polypeptide described herein with high affinity, as well as methods of treating diseases or conditions by administering a binding molecule described herein to a subject in need thereof.[French]
L'invention concerne des procédés d'interrogation d'interactions entre une molécule de liaison et un polypeptide d'intérêt à l'aide d'une spectrométrie de masse à échange d'hydrogène-deutérium, éventuellement en combinaison avec une modélisation in silico de l'interaction de liaison entre la molécule de liaison et le polypeptide. Les polypeptides d'intérêt qui sont interrogés dans un domaine désordonné comprennent, sans s'y limiter, des polypeptides de récepteur d'androgène, des polypeptides d'alpha-synucléine, des polypeptides p27, des polypeptides c-myc et des polypeptides Tau. L'invention concerne en outre l'enrichissement de molécules qui se lient à un polypeptide décrit ici avec une affinité élevée, ainsi que des méthodes de traitement de maladies ou d'états par administration d'une molécule de liaison décrite ici à un sujet en ayant besoin.