WO2026139716 - MECHANICAL MICROFLUIDIC MANIPULATION METHODS AND APPARATUSES
National phase entry is expected:
Publication Number
WO/2026/139716
Publication Date
02.07.2026
International Application No.
PCT/IB2025/000655
International Filing Date
23.12.2025
Title **
[English]
MECHANICAL MICROFLUIDIC MANIPULATION METHODS AND APPARATUSES
[French]
PROCÉDÉS ET APPAREILS DE MANIPULATION MICROFLUIDIQUE MÉCANIQUE
Applicants **
INTEGRA BIOSCIENCES AG
Inventors
CERVANTES, Eduardo
LEE, Cheng-Chang
NAGARAJA, Parimala
LEYCAM, Hyunju
CHRISTODOULOU, Foteini
JEBRAIL, Mais, J.
WIDMER, Dominik
SCHMID, Martin
STEFFEN, Remo
Priority Data
63/738,479
23.12.2024
US
63/738,490
23.12.2024
US
Application details
| Total Number of Claims/PCT | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| 译文 |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 3153 | |
| EPO | Filing, Examination, Granting | 25045 | |
| Japan | Filing, Examination, Granting | 3172 | |
| South Korea | Filing, Examination, Granting | 4321 | |
| USA | Filing, Examination, Granting | 12740 |
Total:
48,431
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Abstract[English]
Disclosed are devices and methods for robust mechanical manipulation of microfluidic droplets within an air gap formed between hydrophobic sheets of a cartridge. A mechanical force applicator locally reduces the gap to draw and translate droplets. Performance is enhanced by adding non‑ionic surfactants, preferably secondary alcohol ethoxylates (e.g., TERGITOL), to set the droplet contact angle to between about 38 and 42 degrees, enabling smooth mobility while reducing fouling. The apparatus may be configured to provide conforming surfaces for the cartridge at the and inlet wells to enhance loading, processing, heating, and retrieval. The methods are compatible with biological samples (e.g., DNA) and can improve sequencing workflows.[French]
La divulgation concerne des dispositifs et des procédés de manipulation mécanique robuste de gouttelettes microfluidiques à l'intérieur d'un entrefer formé entre des feuilles hydrophobes d'une cartouche. Un applicateur de force mécanique réduit localement l'entrefer pour aspirer et déplacer des gouttelettes. Les performances sont améliorées par l'ajout de tensioactifs non ioniques, de préférence des éthoxylates d'alcool secondaire (par exemple, TERGITOL), pour régler l'angle de contact de gouttelettes entre environ 38 et 42 degrés, assurant ainsi une mobilité régulière tout en réduisant l'encrassement. L'appareil peut être conçu pour fournir des surfaces conformes pour la cartouche et des puits d'entrée pour améliorer le chargement, le traitement, le chauffage et la récupération. Les procédés sont compatibles avec des échantillons biologiques (par exemple, de l'ADN) et peuvent améliorer les flux de travail de séquençage.