WO2025134071 - MALIC AND GLUTARIC ACID BASED IONIZABLE LIPIDS

National phase entry is expected:
Publication Number WO/2025/134071
Publication Date 26.06.2025
International Application No. PCT/IB2024/063068
International Filing Date 20.12.2024
Title **
[English] MALIC AND GLUTARIC ACID BASED IONIZABLE LIPIDS
[French] LIPIDES IONISABLES À BASE D'ACIDE MALIQUE ET D'ACIDE GLUTARIQUE
Applicants **
SANOFI
Inventors
DENG, Hongfeng
KARVE, Shrirang
KAUSHAL, Neha
MA, Younan
MIKOCHIK, Peter Justin
NORTHEN, Trent
Priority Data
23307350.1   22.12.2023   EP
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting5568
EPO Filing, Examination, Granting21839
Japan Filing, Examination, Granting2339
South Korea Filing, Examination, Granting2442
USA Filing, Examination, Granting8840
MasterCard Visa
Total: 41,028

The term for entry into the National Phase has expired. This quotation is for informational purposes only

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Abstract[English] Provided herein are ionizable or cationic lipids of Formula (I): (I), or pharmaceutically acceptable salts thereof. The ionizable or cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.[French] L'invention concerne des lipides ionisables ou cationiques de formule (I) : (I), ou des sels pharmaceutiquement acceptables de ceux-ci. Les lipides ionisables ou cationiques selon l'invention peuvent être utiles pour l'administration et l'expression d'ARNm et de protéine codée, par exemple, en tant que composant d'un véhicule d'administration liposomal, et peut par conséquent être utile pour traiter diverses maladies, troubles et états, tels que ceux associés à une déficience d'une ou de plusieurs protéines.