WO2025062359 - ONCOLYTIC ADENOVIRUS AND TOPOISOMERASE I INHIBITORS FOR USE IN TREATING A CANCER

National phase entry:
Publication Number WO/2025/062359
Publication Date 27.03.2025
International Application No. PCT/IB2024/059165
International Filing Date 20.09.2024
Title **
[English] ONCOLYTIC ADENOVIRUS AND TOPOISOMERASE I INHIBITORS FOR USE IN TREATING A CANCER
[French] ADÉNOVIRUS ONCOLYTIQUES ET INHIBITEURS DE TOPOISOMÉRASE I DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT D'UN CANCER
Applicants **
THERIVA BIOLOGICS, S.L.
Inventors
CONNELLY, Sheila
MATO BERCIANO, Ana
Priority Data
63/584,003   20.09.2023   US
63/624,896   25.01.2024   US
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting2982
EPO Filing, Examination, Granting19169
Japan Filing, Examination, Granting2740
South Korea Filing, Examination, Granting3290
USA Filing, Examination, Granting7540
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Total: 35,721

The term for entry into the National Phase has expired. This quotation is for informational purposes only

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Abstract[English] The present disclosure relates, inter alia, to combination therapies of an oncolytic adenovirus with a topoisomerase I inhibitor or prodrug thereof, such as topotecan or SN-38, or a prodrug of a topoisomerase inhibitor, such as irinotecan, for treating or preventing ovarian, cervical, lung, colon or colorectal, and/or pancreatic cancer.[French] La présente divulgation concerne, entre autres, des polythérapies d'un adénovirus oncolytique avec un inhibiteur de topoisomérase I ou un promédicament correspondant, tel que le topotécan ou le SN-38, ou un promédicament d'un inhibiteur de topoisomérase, tel que l'irinotécan, pour le traitement ou la prévention du cancer de l'ovaire, du col de l'utérus, du poumon, du côlon ou du côlon et du rectum, et/ou du pancréas.