WO2025032514 - A PROCESS FOR THE PREPARATION OF SOLID FORMS OF N-[4(CHLORODIFLUOROMETHOXY)PHENYL]-6-[(3R)-3-HYDROXYPYRROLIDIN-1-YL]-5-(1H-PYRAZOL-3-YL) PYRIDINE-3-CARBOXAMIDE HYDROGEN CHLORIDE
National phase entry:
Publication Number
WO/2025/032514
Publication Date
13.02.2025
International Application No.
PCT/IB2024/057635
International Filing Date
07.08.2024
Title **
[English]
A PROCESS FOR THE PREPARATION OF SOLID FORMS OF N-[4(CHLORODIFLUOROMETHOXY)PHENYL]-6-[(3R)-3-HYDROXYPYRROLIDIN-1-YL]-5-(1H-PYRAZOL-3-YL) PYRIDINE-3-CARBOXAMIDE HYDROGEN CHLORIDE
[French]
PROCÉDÉ DE PRÉPARATION DE FORMES SOLIDES DE CHLORURE D'HYDROGÈNE DE N-[4(CHLORODIFLUOROMÉTHOXY)PHÉNYL]-6-[(3R)-3-HYDROXYPYRROLIDIN-1-YL]-5-(1H-PYRAZOL-3-YL)PYRIDINE-3-CARBOXAMIDE
Applicants **
BIOPHORE INDIA PHARMACEUTICALS PVT. LTD
Inventors
PULLAGURLA, Manik Reddy
KOTHAKONDA, Kiran Kumar
PITTA, Bhaskar Reddy
BOGE, Rajesham
RANGISETTY, Jagadeesh Babu
Priority Data
202341052904
07.08.2023
IN
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IP India
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Chapter I
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2087 | |
| EPO | Filing, Examination, Granting | 11999 | |
| Japan | Filing, Examination, Granting | 2000 | |
| South Korea | Filing, Examination, Granting | 1802 | |
| USA | Filing, Examination, Granting | 5940 |
Total:
23,828
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
The present invention relates to a process for the preparation of solid-state forms of N-[4(Chlorodifluoromethoxy)phenyl]-6-[(3R)-3-hydroxypyrrolidin-1-yl]-5-(1H- pyrazol-3-yl) pyridine-3-carboxamide hydrogen chloride. More specifically, the present invention relates to a process for the preparation of solid dispersion of N-[4(Chlorodifluoromethoxy)phenyl]-6-[(3R)-3-hydroxypyrrolidin-1-yl]-5-(1H-pyra zol-3-yl) pyridine-3-carboxamide hydrogen chloride with at least one pharmaceutically acceptable excipient without isolating N-[4 (Chlorodifluoromethoxy)phenyl]-6-[(3R)-3-hydroxypyrrolidin-1-yl]-5-(1H-pyra zol-3-yl) pyridine-3-carboxamide hydrogen chloride. Formula (I).[French]
La présente invention concerne un procédé de préparation de formes à l'état solide de chlorure d'hydrogène de N-[4(chlorodifluorométhoxy)phényl]-6-[(3R)-3-hydroxypyrrolidin-1-yl]-5-(1h-pyrazol-3-yl)pyridine-3-carboxamide. Plus particulièrement, la présente invention concerne un procédé de préparation de dispersion solide de chlorure d'hydrogène de N-[4(chlorodifluorométhoxy)phényl]-6-[(3R)-3-hydroxypyrrolidin-1-yl]-5-(1H-pyra zol-3-yl)pyridine-3-carboxamide avec au moins un excipient pharmaceutiquement acceptable sans isoler le chlorure d'hydrogène de N-[4(chlorodifluorométhoxy)phényl]-6-[(3R)-3-hydroxypyrrolidin-1-yl]-5-(1H-pyrazol-3-yl)pyridine-3-carboxamide. Formule (I).