WO2025168967 - THERMO-RESPONSIVE SUBSTRATE FOR PRODUCING AN INTEGRATED CELL SHEET
National phase entry is expected:
Publication Number
WO/2025/168967
Publication Date
14.08.2025
International Application No.
PCT/IB2024/051162
International Filing Date
08.02.2024
Title **
[English]
THERMO-RESPONSIVE SUBSTRATE FOR PRODUCING AN INTEGRATED CELL SHEET
[French]
SUBSTRAT THERMOSENSIBLE POUR LA PRODUCTION D'UNE FEUILLE CELLULAIRE INTÉGRÉE
Applicants **
ABBASI, Farhang
Inventors
SABZI DIZAJYEKAN, Elham
FADAVI, Moein
NASIRI, Morteza
KAZEMINAVA, Fahimeh
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
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| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
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| Pages of Specification | * |
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International Searching Authority |
IP India
* |
| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
* |
| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Natural Person
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| * | |
| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| 译文 |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2029 | |
| EPO | Filing, Examination, Granting | 8677 | |
| Japan | Filing, Examination, Granting | 2154 | |
| South Korea | Filing, Examination, Granting | 2039 | |
| USA | Filing, Examination, Granting | 5940 |
Total:
20,839
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Abstract[English]
A surface modified substrate comprising at least one thermo-responsive diblock copolymer is developed for producing an integrated cell sheet. The surface modified substrate comprises a diblock copolymer containing poly (N-isopropyl acrylamide) segment. At final step of the preparing method of the surface modified substrate, a direct immersion annealing is applied on a polymeric substrate to modify a surface of the polymeric substrate. The direct immersion annealing can change the surface morphology and roughness that can be suitable for more cell attachment. The produced integrated cell sheet has a dimension of at least 1cm ×1cm.[French]
Un substrat modifié en surface comprenant au moins un copolymère dibloc thermosensible est développé pour produire une feuille cellulaire intégrée. Le substrat à surface modifiée comprend un copolymère dibloc contenant un segment de poly(N-isopropylacrylamide). Lors de l'étape finale du procédé de préparation du substrat à surface modifiée, un recuit par immersion directe est appliqué à un substrat polymère pour modifier une surface du substrat polymère. Le recuit par immersion directe peut modifier la morphologie et la rugosité de surface qui peuvent être appropriées pour une fixation cellulaire supplémentaire. La feuille cellulaire intégrée produite a une dimension d'au moins 1 cm × 1 cm.