WO2024150170 - PIROMELATINE FOR TREATING PARASOMNIAS ASSOCIATED WITH LOSS OF REM SLEEP ATONIA

National phase entry:
Publication Number WO/2024/150170
Publication Date 18.07.2024
International Application No. PCT/IB2024/050296
International Filing Date 11.01.2024
Title **
[English] PIROMELATINE FOR TREATING PARASOMNIAS ASSOCIATED WITH LOSS OF REM SLEEP ATONIA
[French] PIROMÉLATINE POUR LE TRAITEMENT DE PARASOMNIES ASSOCIÉES À UNE PERTE DE L'ATONIE PROPRE AU SOMMEIL PARADOXAL
Applicants **
NEURIM PHARMACEUTICALS (1991) LTD.
Inventors
FURMAN, Ran
ZISAPEL, Nava
Priority Data
63/479,781   13.01.2023   US
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting2609
EPO Filing, Examination, Granting18405
Japan Filing, Examination, Granting2855
South Korea Filing, Examination, Granting3521
USA Filing, Examination, Granting8740
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Total: 36,130

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Abstract[English] Methods of treating a subject having parasomnias related to Rapid Eye Movement (REM) sleep and attenuating disease progression into synucleinopathies and Parkinson's disease by administering a formulation comprising an effective amount of piromelatine to the subject. Methods of treating a subject having parasomnias related to Rapid Eye Movement (REM) sleep and attenuating disease progression of parasomnias into chronic post-traumatic stress disorder (PTSD) by administering a formulation comprising of an effective amount of piromelatine to a subject.[French] L'invention concerne des méthodes de traitement d'un sujet atteint de parasomnies liées au sommeil paradoxal (à mouvement oculaire rapide (MOR)) et d'atténuation de la progression d'une maladie dans des synucléinopathies et la maladie de Parkinson par administration au sujet d'une formulation comprenant une quantité efficace de piromélatine. L'invention concerne également des méthodes de traitement d'un sujet atteint de parasomnies liées au sommeil paradoxal (à mouvement oculaire rapide (MOR)) et d'atténuation de la progression de la maladie de parasomnies en un trouble de stress post-traumatique (TSPT) chronique par l'administration d'une formulation comprenant une quantité efficace de piromélatine à un sujet.