WO2024089638 - NUCLEIC ACID BASED VACCINE

National phase entry:
Publication Number WO/2024/089638
Publication Date 02.05.2024
International Application No. PCT/IB2023/060807
International Filing Date 26.10.2023
Title **
[English] NUCLEIC ACID BASED VACCINE
[French] VACCIN À BASE D'ACIDE NUCLÉIQUE
Applicants **
GLAXOSMITHKLINE BIOLOGICALS SA
Inventors
PETSCH, Benjamin
VAHRENHORST, Dominik
CHAVES MORENO, Diego
GERGEN, Janina
DEVANT, Jessica Michelle
KOVACIKOVA, Kristina
GROBE, Hans Wolfgang
Priority Data
2216023.8   28.10.2022   GB
2300950.9   23.01.2023   GB
2308048.4   30.05.2023   GB
2311985.2   04.08.2023   GB
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting7632
EPO Filing, Examination, Granting29239
Japan Filing, Examination, Granting2587
South Korea Filing, Examination, Granting3049
USA Filing, Examination, Granting10140
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Total: 52,647

The term for entry into the National Phase has expired. This quotation is for informational purposes only

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Abstract[English] The present invention is directed to nucleic acids suitable for use in treatment or prophylaxis of an infection with a coronavirus, such as a Coronavirus SARS-CoV-2 variant, or a disorder related to such an infection, such as COVID-19. The present invention is also directed to compositions, and vaccines. The compositions and vaccines comprise at least one of said nucleic acid sequences, and nucleic acid sequences in association with a lipid nanoparticle (LNP). The invention is also directed to first and second medical uses of the nucleic acids, the composition, the vaccine, and the kit, and to methods of treating or preventing a coronavirus infection, such as a Coronavirus infection from a SARS-CoV-2 variant.[French] La présente invention concerne des acides nucléiques appropriés pour une utilisation dans le traitement ou la prophylaxie d'une infection par un coronavirus, tel qu'un variant du coronavirus SARS-CoV-2 ou un trouble associé à une telle infection, telle que la COVID-19. La présente invention concerne également des compositions et des vaccins. Les compositions et les vaccins comprennent au moins l'une desdites séquences d'acide nucléique et des séquences d'acide nucléique en association avec une nanoparticule lipidique (LNP). L'invention concerne également des première et seconde utilisations médicales des acides nucléiques, de la composition, du vaccin et du kit, ainsi que des méthodes de traitement ou de prévention d'une infection à coronavirus, telle qu'une infection à coronavirus à partir d'un variant du SARS-CoV-2.