WO2024075080 - NEODEGRADER CONJUGATES

National phase entry:
Publication Number WO/2024/075080
Publication Date 11.04.2024
International Application No. PCT/IB2023/060064
International Filing Date 06.10.2023
Title **
[English] NEODEGRADER CONJUGATES
[French] CONJUGUÉS DE NÉO-DÉGRADATEURS
Applicants **
ORUM THERAPEUTICS, INC.
Inventors
FISHKIN, Nathan
KIM, Min-Soo
TAKROURI, Khuloud
PALACINO, James
CHOI, Dong-Ki
KIM, Da-Yeong
JEONG, Hangyeol
Priority Data
63/378,663   06.10.2022   US
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting4131
EPO Filing, Examination, Granting52037
Japan Filing, Examination, Granting3729
South Korea Filing, Examination, Granting3781
USA Filing, Examination, Granting15590
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Total: 79,268

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Abstract[English] The present disclosure provides neoDegraders conjugated to binding moieties that specifically bind to CD56. Also provided are compositions comprising the neoDegrader conjugates. The compounds and compositions are useful for treating a disease or condition, e.g., cancer, in a subject in need thereof.[French] La présente divulgation concerne des néo-dégradateurs (neoDegraders) conjugués à des fractions de liaison qui se lient spécifiquement à CD56. L'invention concerne également des compositions comprenant les conjugués neoDegraders. Les composés et les compositions sont utiles pour traiter une maladie ou un état pathologique, par exemple, un cancer, chez un sujet en ayant besoin.