WO2023187759 - METHODS OF SCREENING COMPOUNDS
National phase entry:
Publication Number
WO/2023/187759
Publication Date
05.10.2023
International Application No.
PCT/IB2023/053283
International Filing Date
31.03.2023
Title **
[English]
METHODS OF SCREENING COMPOUNDS
[French]
PROCÉDÉS DE CRIBLAGE DE COMPOSÉS
Applicants **
DEPIXUS SAS
Inventors
HAMILTON, Gordon
OUELLET, Jimmy
WANG, Zhen
LABUHN, Henning
Priority Data
63/326,370
01.04.2022
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
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| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
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| Pages of Specification | * |
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International Searching Authority |
EPO
* |
| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| 译文 |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2709 | |
| EPO | Filing, Examination, Granting | 15541 | |
| Japan | Filing, Examination, Granting | 2524 | |
| South Korea | Filing, Examination, Granting | 2818 | |
| USA | Filing, Examination, Granting | 6140 |
Total:
29,732
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
Disclosed herein are methods of screening candidate binding compounds to a plurality of target nucleic acids either of the same sequence or of different sequences utilizing a device configured to detect changes in the folding and unfolding force of the target nucleic acid upon binding to various candidate binding compounds. In the presence of a plurality of nucleic acid sequences, the methods described herein also can rapidly determine the specificity of the small molecule or polypeptide to a nucleic acid structure. Also, disclosed herein are methods of measuring binding kinetics of binding compounds to a target nucleic acid using a device configured to detect changes in the folding and unfolding force of the target nucleic acid upon binding to varying concentrations of the candidate binding compound.[French]
L'invention concerne des procédés de criblage de composés de liaison candidats à une pluralité d'acides nucléiques cibles soit de la même séquence soit de séquences différentes à l'aide d'un dispositif conçu pour détecter les changements dans la force de pliage et de dépliage de l'acide nucléique cible lors de la liaison à divers composés de liaison candidats. En présence d'une pluralité de séquences d'acide nucléique, les procédés décrits ici peuvent également déterminer rapidement la spécificité de la petite molécule ou du polypeptide à une structure d'acide nucléique. L'invention concerne également des procédés de mesure de la cinétique de liaison de composés de liaison à un acide nucléique cible à l'aide d'un dispositif conçu pour détecter des changements de la force de pliage et de dépliage de l'acide nucléique cible lors de la liaison à des concentrations variables du composé de liaison candidat.