WO2023152567 - DISRUPTION OF SONIC HEDGEHOG-SURF4 INTERACTION FOR CANCER TREATMENT
National phase entry:
Publication Number
WO/2023/152567
Publication Date
17.08.2023
International Application No.
PCT/IB2023/000075
International Filing Date
10.02.2023
Title **
[English]
DISRUPTION OF SONIC HEDGEHOG-SURF4 INTERACTION FOR CANCER TREATMENT
[French]
PERTURBATION DE L'INTERACTION SONIC HEDGEHOG-SURF4 POUR LE TRAITEMENT DU CANCER
Applicants **
THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
Inventors
GUO, Yusong
TANG, Xiao
WANG, Tingxuan
Priority Data
63/309,648
14.02.2022
US
Application details
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International Searching Authority |
CNIPA
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2456 | |
| EPO | Filing, Examination, Granting | 15472 | |
| Japan | Filing, Examination, Granting | 2246 | |
| South Korea | Filing, Examination, Granting | 2331 | |
| USA | Filing, Examination, Granting | 6390 |
Total:
28,895
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
Provided are compositions and methods that block the interaction between Sonic hedgehog (Shh) and Surfeit locus protein 4 (SURF4), particularly for use in treating subjects with cancer or at risk of suffering from cancer. The subject methods block the interaction between SURF4 and Shh, either by mutating residue E50, D53, D56, or any combination thereof of SURF4 or mutating the CW motif (amino acid residues 32-38) on human Shh. Also provided is a composition comprising a polypeptide that contains the CW motif at the position of 32-38 on human Shh, a polypeptide that contains the first luminal loop (residues 49-60) of human SURF4, or small chemical molecules that block the interaction between SURF4 and Shh and administering said composition to a subject, particularly in subjects with cancer or at risk of suffering from cancer.[French]
La présente invention concerne des compositions et des méthodes qui bloquent l'interaction entre la protéine Sonic hedgehog (Shh) et la protéine 4 du locus Surfeit (SURF4), destinées en particulier à être utilisées dans le traitement de sujets atteints d'un cancer ou présentant un risque de souffrir d'un cancer. Les méthodes selon l'invention bloquent l'interaction entre la protéine SURF4 et la protéine Shh, soit par mutation des résidus E50, D53, D56, soit par une combinaison quelconque associée de la protéine SURF4 ou de mutation du motif CW (résidus d'acides aminés 32-38) sur la protéine Shh humaine. L'invention concerne en outre une composition comprenant un polypeptide qui contient le motif CW en position 32-38 sur la protéine Shh humaine, un polypeptide qui contient la première boucle luminale (résidus 49-60) de la protéine SURF4 humaine, ou de petites molécules chimiques qui bloquent l'interaction entre la protéine SURF4 et la protéine Shh et l'administration de ladite composition à un sujet, en particulier chez des sujets atteints d'un cancer ou présentant un risque de souffrir d'un cancer.