WO2022243913 - COMPOSITIONS AND METHODS FOR ENHANCING VISUAL FUNCTION

National phase entry is expected:
Publication Number WO/2022/243913
Publication Date 24.11.2022
International Application No. PCT/IB2022/054650
International Filing Date 19.05.2022
Title **
[English] COMPOSITIONS AND METHODS FOR ENHANCING VISUAL FUNCTION
[French] COMPOSITIONS ET PROCÉDÉS D'AMÉLIORATION DE LA FONCTION VISUELLE
Applicants **
NOVARTIS AG
Inventors
GUERIN, Karen I.
KOTIN, Robert M.
PASTOR, Eric
REN, Xiaozhi
YOUNG, Sharon
Priority Data
63/191,525   21.05.2021   US
63/292,746   22.12.2021   US
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting3928
EPO Filing, Examination, Granting42174
Japan Filing, Examination, Granting3649
South Korea Filing, Examination, Granting5367
USA Filing, Examination, Granting17390
MasterCard Visa
Total: 72,508

The term for entry into the National Phase has expired. This quotation is for informational purposes only

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Abstract[English] The present disclosure provides compositions and methods of restoring or enhancing visual function in an individual by administering to the individual a pharmaceutical composition comprising a recombinant adeno-associated viral (rAAV) vector having a polynucleotide sequence that encodes a medium wavelength cone opsin (MW-opsin). The MW-opsin is expressed in a retinal cell in the individual, thereby restoring or enhancing visual function.[French] La présente invention concerne des compositions et des procédés de restauration ou d'amélioration de la fonction visuelle chez un individu par administration à l'individu d'une composition pharmaceutique comprenant un vecteur de virus adéno-associé recombinant (rAAV) ayant une séquence polynucléotidique qui code pour une opsine de cône à longueur d'onde moyenne (MW-opsine). La MW-opsine est exprimée dans une cellule rétinienne chez l'individu, ce qui permet de restaurer ou d'améliorer la fonction visuelle.