WO2026125470 - METHOD AND DEVICE FOR THE EARLIEST DETERMINATION OF A PHENOTYPIC TRAIT FROM A STREAM OF GENOMIC SEQUENCES
National phase entry is expected:
Publication Number
WO/2026/125470
Publication Date
18.06.2026
International Application No.
PCT/EP2025/086296
International Filing Date
10.12.2025
Title **
[English]
METHOD AND DEVICE FOR THE EARLIEST DETERMINATION OF A PHENOTYPIC TRAIT FROM A STREAM OF GENOMIC SEQUENCES
[French]
PROCEDE ET DISPOSITIF DE DETERMINATION AU PLUS TOT D'UN CARACTERE PHENOTYPIQUE A PARTIR D'UN FLUX DE SEQUENCES GENOMIQUES
Applicants **
BIOMÉRIEUX
Inventors
EL AZAMI, Meriem
MAHE, Pierre
Priority Data
24219364.7
12.12.2024
EP
25155338.4
31.01.2025
EP
Application details
| Total Number of Claims/PCT | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| 译文 |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2125 | |
| EPO | Filing, Examination, Granting | 8617 | |
| Japan | Filing, Examination, Granting | 2185 | |
| South Korea | Filing, Examination, Granting | 2163 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
19,830
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Abstract[English]
A method for predicting the phenotype of an organism on the basis of the genome thereof comprises sequencing of the genome so as to produce reads, output in real time and/or in batches at regular or periodic intervals, and iterative processing comprising updating of a set of reads on the basis of the new reads that have been output, detection of the k-mers present in the set, phenotypic prediction on the basis of the k-mers detected; and outputting of the prediction when a stop criterion is reached. The stop criterion is reached if the variation in the number of k-mers detected is stable for a predetermined first number of iterations and if the variation in the phenotypic trait is stable for a second number of iterations and if the variation in the sequencing depth between two iterations is greater than a predetermined threshold.[French]
Un procédé de prédiction phénotypique d'un organisme en fonction de son génome, comprend un séquençage du génome de manière à produire des reads, délivrés en temps réel et/ou par lots à intervalles réguliers ou périodiques, et un traitement itératif comprenant une mise à jour d'un ensemble de reads en fonction des nouveaux reads délivrés, une détection des k-mers présents dans l'ensemble, une prédiction phénotypique en fonction des k-mers détectés; et la délivrance de la prédiction lorsqu'un critère d'arrêt est atteint. Le critère d'arrêt est atteint si la variation du nombre de k-mers détectés est stable pendant un premier nombre prédéterminé d'itérations et si la variation du caractère phénotypique est stable pendant un second nombre d'itérations et si la variation de la profondeur de séquençage entre deux itérations est supérieure à un seuil prédéterminé.