WO2026057627 - YEAST FOR INCREASED LIPID PRODUCTION
National phase entry is expected:
Publication Number
WO/2026/057627
Publication Date
19.03.2026
International Application No.
PCT/EP2025/075745
International Filing Date
10.09.2025
Title **
[English]
YEAST FOR INCREASED LIPID PRODUCTION
[French]
LEVURE POUR PRODUCTION ACCRUE DE LIPIDES
Applicants **
VIB VZW
KATHOLIEKE UNIVERSITEIT LEUVEN
Inventors
VERSTREPEN, Kevin
VANGALIS, Vasileios
STEENSELS, Jan
SPAEPEN, Stijn
Priority Data
24386108.5
11.09.2024
EP
Application details
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| 译文 |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2294 | |
| EPO | Filing, Examination, Granting | 10378 | |
| Japan | Filing, Examination, Granting | 2247 | |
| South Korea | Filing, Examination, Granting | 2259 | |
| USA | Filing, Examination, Granting | 5340 |
Total:
22,518
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Abstract[English]
The present invention relates to a recombinant oleaginous yeast cell having at least one CEX1 gene disruption, comprising chimeric gene constructs, each of said chimeric gene constructs comprising a yeast-expressible promoter and a 3' end region comprising transcription termination and polyadenylation signals functioning in a yeast cell, wherein said chimeric gene constructs allow for overexpression of DGA1, ACC1, MCE2, and ACL genes, said ACL gene being ACL1 and/or ACL2 gene. In a second aspect, the invention relates to a method for producing lipids using said transformed oleaginous yeast cell. The invention further pertains to lipids obtainable by the method, a composition comprising said lipids, a composition comprising transformed oleaginous yeast cell, and a food product obtainable therefrom.[French]
La présente invention concerne une cellule de levure oléagineuse recombinante ayant au moins une inactivation de gène CEX1, comprenant des constructions de gènes chimériques, chacune desdites constructions de gènes chimériques comprenant un promoteur exprimable de levure et une région d'extrémité 3' comprenant des signaux de terminaison de transcription et de polyadénylation fonctionnant dans une cellule de levure, lesdites constructions de gènes chimériques permettant la surexpression de gènes DGA1, ACC1, MCE2 et ACL, ledit gène ACL étant un gène ACL1 et/ou ACL2. Selon un second aspect, l'invention concerne un procédé de production de lipides à l'aide de ladite cellule de levure oléagineuse transformée. L'invention concerne en outre des lipides pouvant être obtenus selon le procédé, une composition comprenant lesdits lipides, une composition comprenant une cellule de levure oléagineuse transformée, et un produit alimentaire pouvant être obtenu à partir de celle-ci.