WO2026013265 - NOVEL DIPEPTIDE ACYLATING AGENTS

National phase entry is expected:
Publication Number WO/2026/013265
Publication Date 15.01.2026
International Application No. PCT/EP2025/069911
International Filing Date 11.07.2025
Title **
[English] NOVEL DIPEPTIDE ACYLATING AGENTS
[French] NOUVEAUX AGENTS D'ACYLATION DIPEPTIDIQUES
Applicants **
NOVO NORDISK A/S
Inventors
JENSEN, Kim, Birkebæk
MIKKELSEN, Jesper, Hyldal
Priority Data
24188423.8   12.07.2024   EP
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting2655
EPO Filing, Examination, Granting11046
Japan Filing, Examination, Granting2183
South Korea Filing, Examination, Granting2133
USA Filing, Examination, Granting7590
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Total: 25,607
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Abstract[English] Described are activated esters and oxazolone derivatives comprising the non-canonical amino acid, Aib; methods of making such compounds and methods of using such compounds in a process of making a target peptide comprising Aib. In addition, also the use of an activated dipeptide in a coupling reaction to obtain a target peptide, wherein the activated dipeptide comprises Aib, is described.[French] L'invention concerne des esters et des dérivés oxazolone activés comprenant l'acide aminé non canonique, Aib; des procédés de fabrication de tels composés et des procédés d'utilisation de tels composés dans un procédé de fabrication d'un peptide cible comprenant Aib. De plus, l'invention concerne également l'utilisation d'un dipeptide activé dans une réaction de couplage pour obtenir un peptide cible, le dipeptide activé comprenant Aib.